Toxicity in Kunming mouse implanted with mouse H22 cells assessed as increase in body weight at 25 mg/kg, ig once daily for 12 days measured every 3 days during compound dosing
Antitumor activity against mouse H22 cells implanted in Kunming mouse assessed as tumor growth inhibition at 25 mg/kg, ig once daily for 12 days measured at 24 hrs post last dose relative to control
Immunosuppressive effect in Kunming mouse implanted with mouse H22 cells assessed as liver index at 25 mg/kg, ig once daily for 12 days measured at 24 hrs post last dose (Rvb = 4.17 +/- 0.68%)
Immunosuppressive effect in Kunming mouse implanted with mouse H22 cells assessed as spleen index at 25 mg/kg, ig once daily for 12 days measured at 24 hrs post last dose (Rvb = 0.54 +/- 0.09%)
Immunosuppressive effect in Kunming mouse implanted with mouse H22 cells assessed as thymus index at 25 mg/kg, ig once daily for 12 days measured at 24 hrs post last dose (Rvb = 0.13 +/- 0.06%)
Hepatotoxicity in Kunming mouse implanted with mouse H22 cells assessed as increase in serum ALT level at 25 mg/kg, ig once daily for 12 days measured at 24 hrs post last dose
Hepatotoxicity in Kunming mouse implanted with mouse H22 cells assessed as increase in serum AST level at 25 mg/kg, ig once daily for 12 days measured at 24 hrs post last dose
Immunostimulatory activity in Kunming mouse implanted with mouse H22 cells assessed as increase in serum TNFalpha level at 25 mg/kg, ig once daily for 12 days measured at 24 hrs post last dose by ELISA
Immunostimulatory activity in Kunming mouse implanted with mouse H22 cells assessed as increase in serum IFNgamma level at 25 mg/kg, ig once daily for 12 days measured at 24 hrs post last dose by ELISA
Antitumor activity against mouse H22 cells implanted in Kunming mouse assessed as decrease in nuclear to cytoplasmic ratio at 25 mg/kg, ig once daily for 12 days measured at 24 hrs post last dose by hematoxylin and eosin staining based microscopic method
Antitumor activity against mouse H22 cells implanted in Kunming mouse assessed as necrotic and apoptotic region at 25 mg/kg, ig once daily for 12 days measured at 24 hrs post last dose by hematoxylin and eosin staining based microscopic method