| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4269302 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD | Cryptococcus neoformans | 16 | ALA4265991 | assay format | Scientific Literature | |
| 2. | ALA4269303 | B | Inhibition of recombinant human His-tagged IMPDH1 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD | Homo sapiens | 16 | ALA4265991 | assay format | Scientific Literature | |
| 3. | ALA4269304 | B | Inhibition of recombinant human His-tagged IMPDH2 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD | Homo sapiens | 16 | ALA4265991 | assay format | Scientific Literature | |
| 4. | ALA4269307 | F | Antifungal activity against Candida albicans after 24 hrs by two fold serial dilution method | Candida albicans | 17 | ALA4265991 | organism-based format | Scientific Literature | |
| 5. | ALA4269308 | F | Antifungal activity against Cryptococcus neoformans after 24 hrs by resazurin-dye based two fold serial dilution method | Cryptococcus neoformans | 17 | ALA4265991 | organism-based format | Scientific Literature | |
| 6. | ALA4269309 | A | Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis | Homo sapiens | 16 | ALA4265991 | cell-based format | Scientific Literature | |
| 7. | ALA4269310 | A | Cytotoxicity against human HepG2 cells after 24 hrs by resazurin dye-based fluorescence analysis | Homo sapiens | 16 | ALA4265991 | cell-based format | Scientific Literature | |
| 8. | ALA4269328 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.3 uM assessed as Vmax for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 9. | ALA4269329 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.3 uM assessed as Km for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 257.5 +/- 23 microM) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 10. | ALA4269330 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.3 uM assessed as Kcat for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 21.5 /s) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 11. | ALA4269331 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.3 uM assessed as Vmax for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 12. | ALA4269332 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.3 uM assessed as Km for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 257.5 +/- 23 microM) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 13. | ALA4269333 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.3 uM assessed as Kcat for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 21.5 /s) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 14. | ALA4269334 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 2.5 uM assessed as Vmax for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 15. | ALA4269335 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 2.5 uM assessed as Km for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 257.5 +/- 23 microM) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 16. | ALA4269336 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 2.5 uM assessed as Kcat for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 21.5 /s) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 17. | ALA4269337 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 2.5 uM assessed as Vmax for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 18. | ALA4269338 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 2.5 uM assessed as Km for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 257.5 +/- 23 microM) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 19. | ALA4269339 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 2.5 uM assessed as Kcat for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 21.5 /s) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature | |
| 20. | ALA4269340 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 10 uM assessed as Vmax for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 1.5 microM/min) | Cryptococcus neoformans | 2 | ALA4265991 | assay format | Scientific Literature |
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