# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4261451 | F | Anti-angiogenic activity against HUVEC after 24 hrs by scintillation counting based [3H]-thymidine incorporation assay | Homo sapiens | 27 | ALA4257594 | cell-based format | Scientific Literature | |
2. | ALA4261452 | A | Inhibition of human liver microsome CYP3A4 at 1 uM expressed in baculosomes using fluorogenic-DBOMF as substrate preincubated for 10 mins followed by substrate addition and measured after 60 mins by fluorescence based assay | Homo sapiens | 27 | ALA4257594 | microsome format | Scientific Literature | |
3. | ALA4261453 | F | Antiangiogenic activity in HUVEC assessed as inhibition of tube formation at 5 uM after 24 hrs by matrigel assay relative to control | Homo sapiens | 2 | ALA4257594 | cell-based format | Scientific Literature | |
4. | ALA4261454 | A | Inhibition of human liver microsome CYP3A4 expressed in baculosomes using fluorogenic-DBOMF as substrate preincubated for 10 mins followed by substrate addition and measured after 60 mins by fluorescence based assay | Homo sapiens | 1 | ALA4257594 | microsome format | Scientific Literature | |
5. | ALA4261455 | B | Binding affinity to NPC1 in HUVEC assessed as increase in cholesterol accumulation in late endosome/lysosome at 0.2 uM after 14 hrs by filipin staining-based confocal microscopy | Homo sapiens | 5 | ALA4257594 | cell-based format | Scientific Literature | |
6. | ALA4261456 | B | Binding affinity to VDAC1 in HUVEC assessed as AMPK phosphorylation at Thr172 residue after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4257594 | cell-based format | Scientific Literature | |
7. | ALA4261457 | B | Binding affinity to VDAC1 in HUVEC assessed as ACC1 phosphorylation at Ser79 residue at 0.01 to 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4257594 | cell-based format | Scientific Literature | |
8. | ALA4261458 | B | Binding affinity to NPC1/VDAC1 in HUVEC assessed as reduction in mTOR phosphorylation at Ser2481 residue up to 1 uM after 24 hrs Western blot analysis | Homo sapiens | 1 | ALA4257594 | cell-based format | Scientific Literature | |
9. | ALA4261459 | B | Binding affinity to NPC1/VDAC1 in HUVEC assessed as reduction in mTOR-mediated S6K phosphorylation at Thr389 residue up to 1 uM after 24 hrs Western blot analysis | Homo sapiens | 1 | ALA4257594 | cell-based format | Scientific Literature | |
10. | ALA4261460 | B | Binding affinity to VDAC1 (unknown origin) at 10 uM using itraconazole as probe by photoaffinity probe competitor assay | Homo sapiens | 2 | ALA4257594 | single protein format | Scientific Literature | |
11. | ALA4618799 | B | Inhibition of NPC1/VDAC1 in HUVEC cells assessed as reduction in cell proliferation pretreated for 24 hrs followed by [3H]thymidine incorporation by scintillation counter method | Homo sapiens | 18 | ALA4616691 | cell-based format | Scientific Literature | |
12. | ALA4618800 | P | Thermodynamic solubility in 0.001N HCl by HPLC analysis | 18 | ALA4616691 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4618803 | B | Inhibition of NPC1 in HUVEC cells assessed as accumulation of cholesterol in perinuclear structure at 0.2 uM incubated for 24 hrs by filipin staining based confocal microscopy analysis | Homo sapiens | 5 | ALA4616691 | cell-based format | Scientific Literature | |
14. | ALA4625558 | A | Cytotoxicity against HUVEC assessed as reduction in cell viability | Homo sapiens | 4 | ALA4622958 | cell-based format | Scientific Literature | |
15. | ALA4625559 | A | Inhibition of CYP3A4 (unknown origin) at 1 uM relative to control | Homo sapiens | 4 | ALA4622958 | single protein format | Scientific Literature |