| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4251999 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured for 4 mins by FLIPR assay | Homo sapiens | 170 | cell-based format | Scientific Literature | ||
| 2. | ALA4252000 | A | Apparent permeability in MDCK cells | Canis lupus familiaris | 6 | cell-based format | Scientific Literature | ||
| 3. | ALA4252001 | A | Efflux ratio of apparent permeability in MDCK cells expressing Pgp | Canis lupus familiaris | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA4252002 | A | Efflux ratio of apparent permeability in MDCK cells expressing BCRP | Canis lupus familiaris | 6 | cell-based format | Scientific Literature | ||
| 5. | ALA4252003 | P | Solubility of compound in FaSSIF | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4252004 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 21 | microsome format | Scientific Literature | ||
| 7. | ALA4252009 | A | Clearance in CD1 mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4252010 | A | Volume of distribution at steady state in CD1 mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4252011 | A | Half life in CD1 mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4252012 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 3.2 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4252013 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 1.6 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4252014 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 0.8 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4252015 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 0.4 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4252016 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 0.2 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4252017 | B | Positive allosteric modulation of human GlyRalpha1beta assessed as increase in glycine-induced chloride ion flux by FLIPR assay | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 16. | ALA4252018 | B | Binding affinity to human GlyRalpha3cryst by SPR method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 17. | ALA4252019 | B | Potentiation of human 5-HT3A receptor | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA4252020 | B | Potentiation of human GABAA alpha1beta2gamma2 receptor | Homo sapiens | 1 | protein complex format | Scientific Literature |
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