# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4251999 | Binding | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured for 4 mins by FLIPR assay | Homo sapiens | 170 | ALA4251550 | cell-based format | Scientific Literature | |
2. | ALA4252000 | ADME | Apparent permeability in MDCK cells | Canis lupus familiaris | 6 | ALA4251550 | cell-based format | Scientific Literature | |
3. | ALA4252001 | ADME | Efflux ratio of apparent permeability in MDCK cells expressing Pgp | Canis lupus familiaris | 6 | ALA4251550 | cell-based format | Scientific Literature | |
4. | ALA4252002 | ADME | Efflux ratio of apparent permeability in MDCK cells expressing BCRP | Canis lupus familiaris | 6 | ALA4251550 | cell-based format | Scientific Literature | |
5. | ALA4252003 | Physicochemical | Solubility of compound in FaSSIF | 6 | ALA4251550 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4252004 | ADME | Intrinsic clearance in mouse liver microsomes | Mus musculus | 21 | ALA4251550 | microsome format | Scientific Literature | |
7. | ALA4252009 | ADME | Clearance in CD1 mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA4251550 | organism-based format | Scientific Literature | |
8. | ALA4252010 | ADME | Volume of distribution at steady state in CD1 mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA4251550 | organism-based format | Scientific Literature | |
9. | ALA4252011 | ADME | Half life in CD1 mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA4251550 | organism-based format | Scientific Literature | |
10. | ALA4252012 | Binding | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 3.2 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | ALA4251550 | cell-based format | Scientific Literature | |
11. | ALA4252013 | Binding | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 1.6 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | ALA4251550 | cell-based format | Scientific Literature | |
12. | ALA4252014 | Binding | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 0.8 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | ALA4251550 | cell-based format | Scientific Literature | |
13. | ALA4252015 | Binding | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 0.4 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | ALA4251550 | cell-based format | Scientific Literature | |
14. | ALA4252016 | Binding | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 0.2 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | ALA4251550 | cell-based format | Scientific Literature | |
15. | ALA4252017 | Binding | Positive allosteric modulation of human GlyRalpha1beta assessed as increase in glycine-induced chloride ion flux by FLIPR assay | Homo sapiens | 2 | ALA4251550 | protein complex format | Scientific Literature | |
16. | ALA4252018 | Binding | Binding affinity to human GlyRalpha3cryst by SPR method | Homo sapiens | 2 | ALA4251550 | single protein format | Scientific Literature | |
17. | ALA4252019 | Binding | Potentiation of human 5-HT3A receptor | Homo sapiens | 1 | ALA4251550 | single protein format | Scientific Literature | |
18. | ALA4252020 | Binding | Potentiation of human GABAA alpha1beta2gamma2 receptor | Homo sapiens | 1 | ALA4251550 | protein complex format | Scientific Literature |