| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4269289 | ADME | Drug metabolism assessed as recombinant human CYP4F2 expressed in recombinant insect cell microsomes-mediated omega hydroxylated (13-OH)d6-alpha-tocopheryl quinone formation at 10 uM using BSA bound compound preincubated for 10 mins followed by NADPH addition measured after 20 mins in presence of recombinant human CYP reductase and cytochrome b5 by LS-MS analysis | Homo sapiens | 1 | ALA4265989 | assay format | Scientific Literature | |
| 2. | ALA4269291 | ADME | Drug metabolism assessed as recombinant human CYP4F2 expressed in recombinant insect cell microsomes-mediated d6-13-COOH-alpha-tocopheryl quinone formation at 10 uM using BSA bound compound preincubated for 10 mins followed by NADPH addition measured after 20 mins in presence of recombinant human CYP reductase and cytochrome b5 by LS-MS analysis | Homo sapiens | 1 | ALA4265989 | assay format | Scientific Literature | |
| 3. | ALA4269292 | ADME | Drug level in human liver microsomes treated with BSA bound d6-alpha-tocopheryl quinone assessed as CYP4F2-mediated compound formation by measuring compound retention time at 4.4 mM preincubated for 10 mins followed by NADPH addition measured after 20 mins by LS-MS analysis | Homo sapiens | 4 | ALA4265989 | microsome format | Scientific Literature | |
| 4. | ALA4269293 | ADME | Drug metabolism in human liver microsomes assessed as CYP4F2-mediated d6-alpha-tocopheryl hydroquinone formation using BSA bound compound at 4.4 mM preincubated for 10 mins followed by NADPH addition measured after 20 mins by LC-MS analysis | Homo sapiens | 1 | ALA4265989 | microsome format | Scientific Literature | |
| 5. | ALA4269294 | ADME | Drug metabolism in human liver microsomes assessed as CYP4F2-mediated d6-13-COOH-alpha-tocopheryl quinone formation using BSA bound compound at 4.4 mM preincubated for 10 mins followed by NADPH addition measured after 20 mins by LC-MS analysis | Homo sapiens | 1 | ALA4265989 | microsome format | Scientific Literature | |
| 6. | ALA4269295 | ADME | Drug metabolism in human liver microsomes assessed as CYP4F2-mediated (13-OH)d6-alpha-tocopheryl quinone formation using BSA bound compound at 4.4 mM preincubated for 10 mins followed by NADPH addition measured after 20 mins by LC-MS analysis | Homo sapiens | 1 | ALA4265989 | microsome format | Scientific Literature | |
| 7. | ALA4269298 | ADME | Drug metabolism in human liver microsomes assessed as CYP4F2-mediated omega hydroxylated (13-OH)d6-alpha-tocopheryl quinone formation using BSA bound compound at 4.4 mM incubated for 10 mins in absence of NADPH by LC-MS analysis | Homo sapiens | 1 | ALA4265989 | microsome format | Scientific Literature |
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