| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4274856 | B | Inhibition of SHIP2 (unknown origin) assessed as remaining enzyme activity at 30 uM using PtdIns(3,4,5)P3 as substrate preincubated for 20 mins followed by substrate addition measured for 50 mins by malachite green staining based assay relative to control | Homo sapiens | 46 | single protein format | Scientific Literature | ||
| 2. | ALA4274857 | B | Inhibition of SHIP2 (unknown origin) assessed as decrease in PIP2 production using PtdIns(3,4,5)P3 as substrate preincubated for 20 mins followed by substrate addition measured for 50 mins by malachite green staining based assay | Homo sapiens | 46 | single protein format | Scientific Literature | ||
| 3. | ALA4274858 | A | Inhibition of recombinant human CYP1A2 assessed as remaining enzyme activity at 10 uM preincubated for 5 mins followed by NADPH addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 4. | ALA4274859 | A | Inhibition of recombinant human CYP2C9 assessed as remaining enzyme activity at 10 uM preincubated for 5 mins followed by NADPH addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 5. | ALA4274860 | A | Inhibition of recombinant human CYP2C19 assessed as remaining enzyme activity at 10 uM preincubated for 5 mins followed by NADPH addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 6. | ALA4274861 | A | Inhibition of recombinant human CYP2D6 assessed as remaining enzyme activity at 10 uM preincubated for 5 mins followed by NADPH addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 7. | ALA4274862 | A | Inhibition of recombinant human CYP3A4 assessed as remaining enzyme activity at 10 uM preincubated for 5 mins followed by NADPH addition measured after 20 mins by fluorescence assay relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 8. | ALA4274863 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM preincubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 9. | ALA4274864 | A | Metabolic stability in dog liver microsomes assessed as parent compound remaining at 1 uM preincubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | Canis lupus familiaris | 5 | microsome format | Scientific Literature | ||
| 10. | ALA4274865 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM preincubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | microsome format | Scientific Literature | ||
| 11. | ALA4274866 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 1 uM preincubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 12. | ALA4274867 | A | Cytotoxicity against mouse HT22 cells assessed as decrease in cell viability at 10 uM after 24 hrs by MTT assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA4274868 | B | Inhibition of SHIP2 in mouse HT22 cells assessed as decrease in PI(3,4)P2 production at 10 uM after 24 hrs by mKate2-TAPP1-PH based fluorescence imaging method | Mus musculus | 3 | cell-based format | Scientific Literature |
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