# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4261345 | B | Inhibition of mouse microsomal fraction 17beta-HSD2 at 50 nM using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector based analysis relative to control | Mus musculus | 34 | assay format | Scientific Literature | ||
2. | ALA4261346 | B | Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector based analysis | Homo sapiens | 36 | assay format | Scientific Literature | ||
3. | ALA4261347 | B | Inhibition of human placental cytosolic 17beta-HSD1 using [3H]-E1 as substrate after 10 mins in presence of NADPH by radio-flow detector based analysis | Homo sapiens | 36 | assay format | Scientific Literature | ||
4. | ALA4261350 | B | Selectivity ratio of human placental cytosolic 17beta-HSD1 to IC50 for human placental microsomal fraction 17beta-HSD2 | Homo sapiens | 36 | assay format | Scientific Literature | ||
5. | ALA4261351 | B | Inhibition of mouse microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector based analysis | Mus musculus | 5 | assay format | Scientific Literature | ||
6. | ALA4261354 | B | Inhibition of recombinant mouse 17beta-HSD1 at 1000 nM using [3H]-E1 as substrate after 10 mins in presence of NADPH by radio-flow detector based analysis relative to control | Mus musculus | 36 | single protein format | Scientific Literature | ||
7. | ALA4261356 | P | Aqueous solubility of the compound in phosphate-buffered saline at pH 7.2 after 1 to 24 hrs | 5 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA4261357 | A | Half life in human liver S9 fraction at 1 uM in presence of NADPH regenerating system and UDPGA by L C-MS/MS analysis | Homo sapiens | 5 | subcellular format | Scientific Literature | ||
9. | ALA4261358 | A | Half life in mouse liver S9 fraction at 1 uM in presence of NADPH regenerating system and UDPGA by L C-MS/MS analysis | Mus musculus | 5 | subcellular format | Scientific Literature | ||
10. | ALA4261359 | A | Cmax in C57BL/6 mouse at 50 mg/kg, po by HPLC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
11. | ALA4261361 | A | Tmax in C57BL/6 mouse at 50 mg/kg, po by HPLC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
12. | ALA4261363 | A | Plasma concentration in C57BL/6 mouse at 50 mg/kg, po after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
13. | ALA4261365 | A | AUC (0 to infinity) in C57BL/6 mouse at 50 mg/kg, po by HPLC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
14. | ALA4361953 | B | Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 23 | subcellular format | Scientific Literature | ||
15. | ALA4361955 | B | Selectivity ratio of IC50 for human placental cytosolic fraction 17beta-HSD1 to IC50 for human placental microsomal fraction 17beta-HSD2 | Homo sapiens | 23 | assay format | Scientific Literature | ||
16. | ALA4361956 | B | Inhibition of mouse liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Mus musculus | 15 | tissue-based format | Scientific Literature | ||
17. | ALA4361959 | A | Half life in human liver S9 fraction at 1 uM measured in presence of NADPH generating system | Homo sapiens | 23 | subcellular format | Scientific Literature | ||
18. | ALA4361960 | A | Half life in mouse liver S9 fraction at 1 uM measured in presence of NADPH generating system | Mus musculus | 10 | subcellular format | Scientific Literature | ||
19. | ALA4361961 | P | Aqueous solubility of the compound in pH 7.2 phosphate buffered saline/DMSO | 23 | small-molecule physicochemical format | Scientific Literature | |||
20. | ALA4361966 | A | Time at which plasma concentration stays at in vitro IC50 for mouse liver homogenate 17beta-HSD2 in C57BL/6N mouse at 50 mg/kg, po by HPLC-LC/MS analysis | Mus musculus | 5 | organism-based format | Scientific Literature |