| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4361953 | Binding | Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 23 | ALA4359859 | subcellular format | Scientific Literature | |
| 2. | ALA4361955 | Binding | Selectivity ratio of IC50 for human placental cytosolic fraction 17beta-HSD1 to IC50 for human placental microsomal fraction 17beta-HSD2 | Homo sapiens | 23 | ALA4359859 | assay format | Scientific Literature | |
| 3. | ALA4361956 | Binding | Inhibition of mouse liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Mus musculus | 15 | ALA4359859 | tissue-based format | Scientific Literature | |
| 4. | ALA4361959 | ADME | Half life in human liver S9 fraction at 1 uM measured in presence of NADPH generating system | Homo sapiens | 23 | ALA4359859 | subcellular format | Scientific Literature | |
| 5. | ALA4361960 | ADME | Half life in mouse liver S9 fraction at 1 uM measured in presence of NADPH generating system | Mus musculus | 10 | ALA4359859 | subcellular format | Scientific Literature | |
| 6. | ALA4361961 | Physicochemical | Aqueous solubility of the compound in pH 7.2 phosphate buffered saline/DMSO | 23 | ALA4359859 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4361966 | ADME | Time at which plasma concentration stays at in vitro IC50 for mouse liver homogenate 17beta-HSD2 in C57BL/6N mouse at 50 mg/kg, po by HPLC-LC/MS analysis | Mus musculus | 5 | ALA4359859 | organism-based format | Scientific Literature | |
| 8. | ALA4364724 | Binding | Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 15 | ALA4364247 | subcellular format | Scientific Literature | |
| 9. | ALA4364725 | Binding | Selectivity index, ratio of IC50 for human placental cytosolic fraction 17beta-HSD1 to IC50 for human placental microsomal fraction 17beta-HSD2 | Homo sapiens | 15 | ALA4364247 | assay format | Scientific Literature | |
| 10. | ALA4364727 | Binding | Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 15 | ALA4364247 | assay format | Scientific Literature | |
| 11. | ALA4364729 | Binding | Inhibition of mouse liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Mus musculus | 3 | ALA4364247 | tissue-based format | Scientific Literature | |
| 12. | ALA4364732 | ADME | Half life in human liver S9 fraction at 1 uM in presence of NADPH | Homo sapiens | 14 | ALA4364247 | subcellular format | Scientific Literature | |
| 13. | ALA4364733 | Physicochemical | Aqueous solubility of the compound in phosphate-buffered saline at pH 7.2 after 1 to 24 hrs | 11 | ALA4364247 | small-molecule physicochemical format | Scientific Literature | ||
| 14. | ALA4261345 | Binding | Inhibition of mouse microsomal fraction 17beta-HSD2 at 50 nM using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector based analysis relative to control | Mus musculus | 34 | ALA4257592 | assay format | Scientific Literature | |
| 15. | ALA4261346 | Binding | Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector based analysis | Homo sapiens | 36 | ALA4257592 | assay format | Scientific Literature | |
| 16. | ALA4261347 | Binding | Inhibition of human placental cytosolic 17beta-HSD1 using [3H]-E1 as substrate after 10 mins in presence of NADPH by radio-flow detector based analysis | Homo sapiens | 36 | ALA4257592 | assay format | Scientific Literature | |
| 17. | ALA4261350 | Binding | Selectivity ratio of human placental cytosolic 17beta-HSD1 to IC50 for human placental microsomal fraction 17beta-HSD2 | Homo sapiens | 36 | ALA4257592 | assay format | Scientific Literature | |
| 18. | ALA4261351 | Binding | Inhibition of mouse microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector based analysis | Mus musculus | 5 | ALA4257592 | assay format | Scientific Literature | |
| 19. | ALA4261354 | Binding | Inhibition of recombinant mouse 17beta-HSD1 at 1000 nM using [3H]-E1 as substrate after 10 mins in presence of NADPH by radio-flow detector based analysis relative to control | Mus musculus | 36 | ALA4257592 | single protein format | Scientific Literature | |
| 20. | ALA4261356 | Physicochemical | Aqueous solubility of the compound in phosphate-buffered saline at pH 7.2 after 1 to 24 hrs | 5 | ALA4257592 | small-molecule physicochemical format | Scientific Literature |
The page will load shortly, Thanks for your patience!