# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4265322 | B | Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assay | Homo sapiens | 118 | ALA4261639 | single protein format | Scientific Literature | |
2. | ALA4265323 | B | Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured after 1 hr by Alexofluor 488-conjugated secondary antibody and Hoechst 33342 staining based assay | Homo sapiens | 50 | ALA4261639 | cell-based format | Scientific Literature | |
3. | ALA4265329 | T | Selectivity ratio of cytotoxicity for human HeLa cells to EC50 for human full length PARG | Homo sapiens | 5 | ALA4261639 | cell-based format | Scientific Literature | |
4. | ALA4265330 | A | Clearance in human liver microsomes | Homo sapiens | 20 | ALA4261639 | microsome format | Scientific Literature | |
5. | ALA4265331 | A | Clearance in mouse liver microsomes | Mus musculus | 6 | ALA4261639 | microsome format | Scientific Literature | |
6. | ALA4265332 | P | Solubility of the compound | 2 | ALA4261639 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4265333 | A | Apparent permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 2 | ALA4261639 | cell-based format | Scientific Literature | |
8. | ALA4265334 | A | Efflux ratio of apparent permeability in human Caco2 cells | Homo sapiens | 2 | ALA4261639 | cell-based format | Scientific Literature | |
9. | ALA4265335 | A | Inhibition of CYP1A (unknown origin) | Homo sapiens | 2 | ALA4261639 | protein format | Scientific Literature | |
10. | ALA4265336 | A | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 2 | ALA4261639 | single protein format | Scientific Literature | |
11. | ALA4265337 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 2 | ALA4261639 | single protein format | Scientific Literature | |
12. | ALA4265338 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | ALA4261639 | single protein format | Scientific Literature | |
13. | ALA4265339 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 2 | ALA4261639 | single protein format | Scientific Literature | |
14. | ALA4265340 | A | AUC in CD1 mouse at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Mus musculus | 2 | ALA4261639 | organism-based format | Scientific Literature | |
15. | ALA4265341 | A | Half life in CD1 mouse at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Mus musculus | 2 | ALA4261639 | organism-based format | Scientific Literature | |
16. | ALA4265342 | A | Volume of distribution in CD1 mouse at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Mus musculus | 2 | ALA4261639 | organism-based format | Scientific Literature | |
17. | ALA4265343 | A | Clearance in CD1 mouse at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Mus musculus | 2 | ALA4261639 | organism-based format | Scientific Literature | |
18. | ALA4265344 | A | Oral bioavailability in CD1 mouse at 5 mg/kg administered as single dose by LC-MS/MS analysis | Mus musculus | 2 | ALA4261639 | organism-based format | Scientific Literature | |
19. | ALA4265345 | A | Clearance in mouse hepatocytes assessed per million cells | Mus musculus | 2 | ALA4261639 | cell-based format | Scientific Literature |