| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4256562 | B | Inhibition of recombinant mouse N-terminal FLAG-tagged Notch1 (1704 to 2531 residues) expressed in human LS174T cells assessed as reduction in doxycycline-induced NICD expression after 12 hrs by Bright-Glo luciferase reporter gene assay | Mus musculus | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA4256563 | F | Effect on Notch1 mRNA expression in human HPBALL cells at 0.1 to 0.5 uM measured after 12 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4256564 | B | Inhibition of Notch1 in human HPBALL cells assessed as reduction in NICD expression at 0.5 uM after 12 hrs in presence of proteasome inhibitor MG132 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4256565 | F | Down regulation of Notch1 expression in human HPBALL cells at 0.5 uM after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4256566 | B | Inhibition of Notch1 in human HPBALL cells assessed as reduction in HES1 expression after 72 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4256567 | B | Inhibition of Notch1 in human HPBALL cells assessed as reduction in NICD expression at 0.5 uM after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4256568 | B | Inhibition of Notch1 in human HPBALL cells assessed as reduction in NICD expression after 72 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4256569 | A | Cytotoxicity against HEK293 cells after 72 hrs by fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4256570 | F | Cytotoxicity against human HPBALL cells after 72 hrs by alamar blue dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4256571 | F | Down regulation of Notch1 expression in human HPBALL cells at 0.5 uM after 12 hrs in presence of proteasome inhibitor MG132 by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4256572 | B | Inhibition of doxycycline-induced recombinant mouse N-terminal FLAG-tagged Notch1 (1704 to 2531 residues) activation expressed in human LS174T cells assessed as reduction in Hes1 level at 0.05 to 0.3 uM after 12 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4256573 | B | Inhibition of doxycycline-induced recombinant mouse N-terminal FLAG-tagged Notch1 (1704 to 2531 residues) activation expressed in human LS174T cells assessed as reduction in Hes5 level at 0.05 to 0.3 uM after 12 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4256574 | F | Inhibition of doxycycline-induced Notch1 (1704 to 2531 residues) expression in human LS174T cells after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4256575 | B | Inhibition of doxycycline-induced recombinant mouse N-terminal FLAG-tagged Notch1 (1704 to 2531 residues) activation expressed in human LS174T cells assessed as reduction in NCID expression after 12 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4256576 | B | Inhibition of doxycycline-induced recombinant mouse N-terminal FLAG-tagged Notch1 (1704 to 2531 residues) activation expressed in human LS174T cells assessed as reduction in NCID expression at 0.5 uM after 12 hrs in presence of proteasome inhibitor MG132 by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4303805 | F | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging | Homo sapiens | 5,612 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | ||
| 17. | ALA4368044 | F | Antiproliferative activity against human CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 18. | ALA4368045 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 19. | ALA4368046 | F | Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 20. | ALA4368047 | F | Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay | Homo sapiens | 9 | cell-based format | Scientific Literature |
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