# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4268600 | Binding | Inhibition of recombinant human SCD1 expressed in baculovirus expression system assessed as reduction in [3H]H2O production using stearoyl [9,10-3H]CoA as substrate in presence of NADH incubated for 30 mins by scintillation counting method | Homo sapiens | 52 | ALA4265954 | assay format | Scientific Literature | |
2. | ALA4268607 | Functional | Ex vivo inhibition of SCD1 in C57BL/6J mouse liver assessed as residual activity at 1 mg/kg, po treated for 6 hrs followed by incubation with [14C]stearoyl-CoA substrate for 10 mins by TLC assay relative to control | Mus musculus | 27 | ALA4265954 | organism-based format | Scientific Literature | |
3. | ALA4268610 | ADME | Ex vivo inhibition of SCD1 in C57BL/6J mouse eyelid assessed as residual activity at 1 mg/kg, po treated for 6 hrs followed by incubation with [14C]stearoyl-CoA substrate for 30 mins by TLC assay relative to control | Mus musculus | 27 | ALA4265954 | organism-based format | Scientific Literature |