| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4259984 | B | Selectivity ratio of IC50 for inhibition of recombinant His6-tagged human Max homodimer/HEX-tagged double-stranded oligonucleotide complex formation to IC50 for inhibition of recombinant His6-tagged bHLH-LZ domain of human Myc/His6-tagged human Max/HEX-tagged double-stranded oligonucleotide complex formation | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA4259985 | B | Binding affinity to recombinant His6-tagged bHLH-LZ domain of human Myc expressed in Escherichia coli strain BL21DE3(plysS) assessed as inhibition of protein/His6-tagged human Max/HEX-tagged double-stranded oligonucleotide complex formation preincubated for 90 mins followed by oligonucleotide adition and measured after 15 mins by electrophoretic mobility shift assays | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 3. | ALA4482471 | B | Inhibition of His6-tagged homogeneously purified recombinant Myc bHLH-LZ domain (unknown origin)/His6-tagged Max (151 residues) (unknown origin) interaction assessed as reduction in Myc/Max/DNA ternary complex formation using fluorescently-tagged (FAM) E-Box-containing double-stranded oligonucleotide at 100 uM by EMSA relative to control | Homo sapiens | 66 | protein complex format | Patent Bioactivity Data | ||
| 4. | ALA4482473 | B | Inhibition of His6-tagged Max (160 amino acids) (unknown origin) assessed as reduction in Max/Max homodimer formation assessed as reduction in Max/Max/DNA ternary complex formation using fluorescently-tagged (FAM) E-Box-containing double-stranded oligonucleotide at by EMSA | Homo sapiens | 9 | single protein format | Patent Bioactivity Data | ||
| 5. | ALA4482475 | F | Antiproliferative activity against human HL60 cells assessed as reduction in cell proliferation incubated for 3 to 4 days by MTT assay | Homo sapiens | 15 | cell-based format | Patent Bioactivity Data | ||
| 6. | ALA4482476 | F | Antiproliferative activity against human Daudi cells assessed as reduction in cell proliferation incubated for 3 to 4 days by MTT assay | Homo sapiens | 15 | cell-based format | Patent Bioactivity Data | ||
| 7. | ALA4482479 | B | Inhibition of His6-tagged homogeneously purified recombinant Myc bHLH-LZ domain (unknown origin)/His6-tagged Max (151 residues) (unknown origin) interaction assessed as reduction in Myc/Max/DNA ternary complex formation using fluorescently-tagged (FAM) E-Box-containing double-stranded oligonucleotide by EMSA relative to control | Homo sapiens | 9 | protein complex format | Patent Bioactivity Data | ||
| 8. | ALA4482480 | F | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at G0/G1 phase incubated for 24 to 48 hrs by propidium iodide staining based flow cytometric analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 9. | ALA4482481 | F | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at G0/G1 phase at 5 uM incubated for 24 to 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 36%) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 10. | ALA4482482 | F | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at G2/M phase at 5 uM incubated for 24 to 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 14%) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 11. | ALA4482483 | F | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 5 uM incubated for 24 to 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 50%) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 12. | ALA4482484 | F | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at G0/G1 phase at 10 uM incubated for 24 to 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 36%) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 13. | ALA4482485 | F | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at G2/M phase at 10 uM incubated for 24 to 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 14%) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 14. | ALA4482486 | F | Induction of cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 10 uM incubated for 24 to 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 50%) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 15. | ALA4482487 | B | Inhibition of Myc in human HL60 cells co-transfected with Myc-responsive E-box elements assessed as reduction c-Myc promoter-mediated luciferase expression at 10 to 50 uM after 6 hrs | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 16. | ALA5235463 | F | Cytotoxicity against human HL-60 cells measured after 72 hrs by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 17. | ALA5236767 | B | Inhibition of Myc/Max (unknown origin) | Homo sapiens | 4 | protein format | Scientific Literature | ||
| 18. | ALA5236768 | F | Antiproliferative activity against (unknown origin) HL-60 assessed as inhibition of cell proliferation by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 19. | ALA5236769 | F | Antiproliferative activity against human Daudi assessed as inhibition of cell proliferation by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!