| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4269980 | B | Inhibition of methicillin-resistant Staphylococcus aureus USA300 SaeRS assessed as reduction in alpha-hemolysin mediated hemolysis of human erythrocytes at 8 uM after 8 hrs by ELISA | Staphylococcus aureus subsp. aureus USA300 | 2 | ALA4266038 | assay format | Scientific Literature | |
| 2. | ALA4269981 | B | Inhibition of methicillin-resistant Staphylococcus aureus USA300 SaeRS assessed as reduction in alpha-hemolysin mediated hemolysis of human erythrocytes at 4 uM after 8 hrs by ELISA | Staphylococcus aureus subsp. aureus USA300 | 2 | ALA4266038 | assay format | Scientific Literature | |
| 3. | ALA4269983 | B | Inhibition of Staphylococcus aureus USA300 GFP-fused SaeRS after 8 hrs by fluorescence-based assay | Staphylococcus aureus subsp. aureus USA300 | 2 | ALA4266038 | assay format | Scientific Literature | |
| 4. | ALA4269986 | A | Growth inhibition of Staphylococcus aureus USA300 up to 64 uM after 8 to 20 hrs | Staphylococcus aureus | 1 | ALA4266038 | organism-based format | Scientific Literature | |
| 5. | ALA4269987 | B | Inhibition of Staphylococcus aureus USA300 SaeRS expressed in Escherichia coli BL21(DE3) assessed as reduction in alpha-hemolysin mediated hemolysis in human erythrocytes after 8 hrs by ELISA | Staphylococcus aureus subsp. aureus USA300 | 2 | ALA4266038 | cell-based format | Scientific Literature | |
| 6. | ALA4269992 | B | Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in alpha-hemolysin gene expression at 10 uM after 6 hrs by qRT-PCR analysis | Staphylococcus aureus subsp. aureus USA300 | 1 | ALA4266038 | assay format | Scientific Literature | |
| 7. | ALA4269993 | B | Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in aureolysin gene expression at 10 uM after 6 hrs by qRT-PCR analysis | Staphylococcus aureus subsp. aureus USA300 | 1 | ALA4266038 | assay format | Scientific Literature | |
| 8. | ALA4269994 | B | Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in gamma-hemolysin gene expression at 10 uM after 6 hrs by qRT-PCR analysis | Staphylococcus aureus subsp. aureus USA300 | 1 | ALA4266038 | assay format | Scientific Literature | |
| 9. | ALA4269995 | B | Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in staphylokinase gene expression at 10 uM after 6 hrs by qRT-PCR analysis | Staphylococcus aureus subsp. aureus USA300 | 1 | ALA4266038 | assay format | Scientific Literature | |
| 10. | ALA4269997 | F | Reduction in Staphylococcus aureus USA300 sarA gene expression at 10 uM after 6 hrs by qRT-PCR analysis | Staphylococcus aureus | 1 | ALA4266038 | assay format | Scientific Literature | |
| 11. | ALA4269998 | A | Cytotoxicity against human HeLa cells assessed as reduction in cell survival after 72 hrs by LDH reduction assay | Homo sapiens | 2 | ALA4266038 | cell-based format | Scientific Literature | |
| 12. | ALA4269999 | A | Cytotoxicity against human HeLa cells assessed as reduction in cell viability at 8 uM after 72 hrs by fluorescein diacetate/propidium iodide double staining based confocal microscopy | Homo sapiens | 2 | ALA4266038 | cell-based format | Scientific Literature | |
| 13. | ALA4270000 | A | Cytotoxicity against human HeLa cells assessed as reduction in cell viability at >IC50 concentration after 72 hrs by fluorescein diacetate/propidium iodide double staining based confocal microscopy | Homo sapiens | 2 | ALA4266038 | cell-based format | Scientific Literature | |
| 14. | ALA4270001 | F | Antivirulence activity in Staphylococcus aureus USA300-infected Galleria mellonella larvae model injected at every 12 h interval for 72 hrs | Staphylococcus aureus | 2 | ALA4266038 | organism-based format | Scientific Literature | |
| 15. | ALA4270003 | F | Antivirulence activity in Staphylococcus aureus USA300-infected Galleria mellonella larvae model assessed as increase in larvae survival at 2.1 mg/kg injected at 2 hrs post infection at every 12 hr interval for 72 hrs relative to control | Staphylococcus aureus | 1 | ALA4266038 | organism-based format | Scientific Literature | |
| 16. | ALA4270006 | F | Antivirulence activity in Staphylococcus aureus USA300-infected Galleria mellonella larvae model assessed as larvae survival at 3.2 mg/kg injected at 2 hrs post infection at every 12 hr interval for 72 hrs (Rvb = 20%) | Staphylococcus aureus | 1 | ALA4266038 | organism-based format | Scientific Literature | |
| 17. | ALA4270007 | F | Antivirulence activity in Staphylococcus aureus USA300-infected Galleria mellonella larvae model assessed as larvae survival at 4.3 mg/kg injected at 2 hrs post infection at every 12 hr interval for 72 hrs (Rvb = 20%) | Staphylococcus aureus | 1 | ALA4266038 | organism-based format | Scientific Literature | |
| 18. | ALA4270008 | F | Antibacterial activity against Staphylococcus aureus USA300 assessed as log reduction in bacterial burden after 72 hrs | Staphylococcus aureus | 2 | ALA4266038 | organism-based format | Scientific Literature | |
| 19. | ALA4270010 | F | Antibacterial activity against Staphylococcus aureus USA300 assessed as log reduction in bacterial burden at 4.3 mg/kg after 72 hrs | Staphylococcus aureus | 1 | ALA4266038 | organism-based format | Scientific Literature | |
| 20. | ALA4270011 | F | Antivirulence activity in SaeS Tn551 deletion mutant harboring Staphylococcus aureus USA300-infected Galleria mellonella model assessed as survival rate at 2.131 mg/kg injected at 2 hrs post infection at every 12 hr interval for 72 hrs (Rvb = 80%) | Staphylococcus aureus | 1 | ALA4266038 | organism-based format | Scientific Literature |
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