| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4253251 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells assessed as inhibition of viral RNA replication after 72 hrs by qRT-PCR method | Hepacivirus hominis | 36 | ALA4251597 | organism-based format | Scientific Literature | |
| 2. | ALA4253252 | A | Cytotoxicity against human Huh7.5 cells after 72 hrs by MTT assay | Homo sapiens | 36 | ALA4251597 | cell-based format | Scientific Literature | |
| 3. | ALA4253253 | T | Selectivity index, ratio of CC50 for human Huh7.5 cells to EC50 for HCV J6/JFH/JC-1 | 35 | ALA4251597 | assay format | Scientific Literature | ||
| 4. | ALA4253254 | A | Tmax in mouse at 25 mg/kg, po after 0.25 to 6 hrs | Mus musculus | 3 | ALA4251597 | organism-based format | Scientific Literature | |
| 5. | ALA4253255 | A | Cmax in mouse at 25 mg/kg, po after 0.25 to 6 hrs | Mus musculus | 3 | ALA4251597 | organism-based format | Scientific Literature | |
| 6. | ALA4253256 | A | AUC (0 to t) in mouse at 25 mg/kg, po after 0.25 to 6 hrs | Mus musculus | 3 | ALA4251597 | organism-based format | Scientific Literature | |
| 7. | ALA4253257 | A | MRT in mouse at 25 mg/kg, po after 0.25 to 6 hrs | Mus musculus | 3 | ALA4251597 | organism-based format | Scientific Literature | |
| 8. | ALA4253258 | A | Half life in mouse at 25 mg/kg, po after 0.25 to 6 hrs | Mus musculus | 3 | ALA4251597 | organism-based format | Scientific Literature | |
| 9. | ALA4253259 | T | Acute toxicity in po dosed Kunming mouse measured for 7 days | Mus musculus | 2 | ALA4251597 | organism-based format | Scientific Literature | |
| 10. | ALA4253260 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells assessed as inhibition of NS3/4A levels after 72 hrs by Western blot method | Hepacivirus hominis | 1 | ALA4251597 | organism-based format | Scientific Literature | |
| 11. | ALA4253261 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells assessed as inhibition of viral core protein levels after 72 hrs by Western blot method | Hepacivirus hominis | 1 | ALA4251597 | organism-based format | Scientific Literature | |
| 12. | ALA4253262 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells assessed as inhibition of viral core protein levels at 0.5 uM by Western blot method | Hepacivirus hominis | 2 | ALA4251597 | organism-based format | Scientific Literature | |
| 13. | ALA4253263 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells assessed as inhibition of NS3/4A protein levels at 0.5 uM by Western blot method | Hepacivirus hominis | 2 | ALA4251597 | organism-based format | Scientific Literature | |
| 14. | ALA4253270 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells assessed as inhibition of NS3/4A A156T mutant levels at 20 uM treated with fresh media containing compound every 2 days by Western blot method | Hepacivirus hominis | 1 | ALA4251597 | organism-based format | Scientific Literature | |
| 15. | ALA4253271 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells assessed as inhibition of NS3/4A D168V mutant levels at 20 uM treated with fresh media containing compound every 2 days by Western blot method | Hepacivirus hominis | 1 | ALA4251597 | organism-based format | Scientific Literature | |
| 16. | ALA4253272 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells assessed as inhibition of NS3/4A S282T mutant levels at 20 uM treated with fresh media containing compound every 2 days by Western blot method | Hepacivirus hominis | 1 | ALA4251597 | organism-based format | Scientific Literature | |
| 17. | ALA4253273 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells harboring NS3/4A A156T mutant assessed as inhibition of viral core protein levels at 20 uM treated with fresh media containing compound every 2 days by Western blot method | Hepacivirus hominis | 1 | ALA4251597 | organism-based format | Scientific Literature | |
| 18. | ALA4253274 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells harboring NS3/4A D168V mutant assessed as inhibition of viral core protein levels at 20 uM treated with fresh media containing compound every 2 days by Western blot method | Hepacivirus hominis | 1 | ALA4251597 | organism-based format | Scientific Literature | |
| 19. | ALA4253275 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells harboring NS3/4A S282T mutant assessed as inhibition of viral core protein levels at 20 uM treated with fresh media containing compound every 2 days by Western blot method | Hepacivirus hominis | 1 | ALA4251597 | organism-based format | Scientific Literature | |
| 20. | ALA4253276 | F | Antiviral activity against HCV J6/JFH/JC-1 infected in human Huh7.5 cells assessed as inhibition of NS3/4A levels at 10 uM treated with fresh media containing compound every 2 days in presence of NS3/4A inhibitor simeprevir by Western blot method | Hepacivirus hominis | 1 | ALA4251597 | organism-based format | Scientific Literature |
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