| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4267189 | B | Inhibition of Smo-mediated hedgehog signaling pathway in mouse C3H10T1/2 cells after 6 days by Gli-dependent luciferase reporter gene assay | Mus musculus | 3 | ALA4265903 | cell-based format | Scientific Literature | |
| 2. | ALA4274761 | B | Inhibition of hedgehog signaling pathway in mouse Light2 cells in Shh conditioned medium after 30 hrs by Gli-Renilla luciferase reporter gene assay | Mus musculus | 5 | ALA4270604 | cell-based format | Scientific Literature | |
| 3. | ALA4274762 | B | Inhibition of hedgehog signaling pathway-mediated differentiation of mouse C3H10T1/2 cells assessed as decrease in SAG-induced ALP activity after 6 days by chemiluminescence-based assay | Mus musculus | 5 | ALA4270604 | assay format | Scientific Literature | |
| 4. | ALA4274763 | F | Antiproliferative activity against human LS180 cells after 72 hrs by sulforhodamine-B assay | Homo sapiens | 5 | ALA4270604 | cell-based format | Scientific Literature | |
| 5. | ALA4274764 | F | Antiproliferative activity against human HT1080 cells after 72 hrs by sulforhodamine-B assay | Homo sapiens | 5 | ALA4270604 | cell-based format | Scientific Literature | |
| 6. | ALA4274765 | F | Antitumor activity against human LS180 cells xenografted in athymic nude mouse assessed as tumor growth inhibition at 200 mg/kg, po administered 5 days per week for 2 weeks relative to vehicle-treated control | Homo sapiens | 1 | ALA4270604 | organism-based format | Scientific Literature | |
| 7. | ALA4274766 | T | Toxicity in athymic nude mouse xenografted with human LS180 cells assessed as body weight loss at 200 mg/kg, po administered 5 days per week for 2 weeks | Mus musculus | 1 | ALA4270604 | organism-based format | Scientific Literature | |
| 8. | ALA4274767 | B | Substrate activity at recombinant human P-gp in membrane fraction assessed as increase in ATPase activity at 10 uM by luminescent P-gp-Glo assay relative to control | Homo sapiens | 5 | ALA4270604 | assay format | Scientific Literature | |
| 9. | ALA4274768 | A | Apparent permeability of the compound from apical to basolateral side in human Caco2 cells after 120 mins by LC-MS/MS analysis | Homo sapiens | 6 | ALA4270604 | cell-based format | Scientific Literature | |
| 10. | ALA4274769 | A | Apparent permeability of the compound from apical to basolateral side in human Caco2 cells assessed as drug recovery after 120 mins by LC-MS/MS analysis | Homo sapiens | 7 | ALA4270604 | cell-based format | Scientific Literature | |
| 11. | ALA4274770 | A | Apparent permeability of the compound from basolateral to apical side in human Caco2 cells after 120 mins by LC-MS/MS analysis | Homo sapiens | 6 | ALA4270604 | cell-based format | Scientific Literature | |
| 12. | ALA4274771 | A | Apparent permeability of the compound from basolateral to apical side in human Caco2 cells assessed as drug recovery after 120 mins by LC-MS/MS analysis | Homo sapiens | 7 | ALA4270604 | cell-based format | Scientific Literature | |
| 13. | ALA4274772 | A | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in human Caco2 cells after 120 mins by LC-MS/MS analysis | Homo sapiens | 6 | ALA4270604 | cell-based format | Scientific Literature | |
| 14. | ALA4274773 | A | Inhibition of recombinant human CYP1A2 expressed in insect cell microsomes at 1 uM using Luciferin-ME as substrate preincubated for 10 mins followed by NADPH addition measured after 30 mins by luminometric method | Homo sapiens | 5 | ALA4270604 | assay format | Scientific Literature | |
| 15. | ALA4274774 | A | Inhibition of recombinant human CYP3A4 expressed in insect cell microsomes at 1 uM using Luciferin-IPA as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins by luminometric method | Homo sapiens | 4 | ALA4270604 | assay format | Scientific Literature | |
| 16. | ALA4274775 | A | Inhibition of recombinant human CYP1A2 expressed in insect cell microsomes at 5 uM using Luciferin-ME as substrate preincubated for 10 mins followed by NADPH addition measured after 30 mins by luminometric method | Homo sapiens | 4 | ALA4270604 | assay format | Scientific Literature | |
| 17. | ALA4274776 | A | Inhibition of recombinant human CYP1A2 expressed in insect cell microsomes at 10 uM using Luciferin-ME as substrate preincubated for 10 mins followed by NADPH addition measured after 30 mins by luminometric method | Homo sapiens | 4 | ALA4270604 | assay format | Scientific Literature | |
| 18. | ALA4274777 | A | Inhibition of recombinant human CYP3A4 expressed in insect cell microsomes at 5 uM using Luciferin-IPA as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins by luminometric method | Homo sapiens | 5 | ALA4270604 | assay format | Scientific Literature | |
| 19. | ALA4274778 | A | Inhibition of recombinant human CYP3A4 expressed in insect cell microsomes at 10 uM using Luciferin-IPA as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins by luminometric method | Homo sapiens | 4 | ALA4270604 | assay format | Scientific Literature | |
| 20. | ALA4274779 | A | Inhibition of recombinant human CYP2C9 expressed in insect cell microsomes at 1 uM using Luciferin-H as substrate preincubated for 30 mins followed by NADPH addition measured after 30 mins by luminometric method | Homo sapiens | 4 | ALA4270604 | assay format | Scientific Literature |
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