| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4265206 | F | Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay | Homo sapiens | 42 | ALA4261634 | cell-based format | Scientific Literature | |
| 2. | ALA4265207 | F | Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay relative to linoleic acid | Homo sapiens | 41 | ALA4261634 | cell-based format | Scientific Literature | |
| 3. | ALA4265209 | F | Antidiabetic activity in Sprague-Dawley rat assessed as reduction in blood glucose excursion at 10 to 20 mg/kg, po administered 60 mins prior to glucose challenge by OGTT | Rattus norvegicus | 3 | ALA4261634 | organism-based format | Scientific Literature | |
| 4. | ALA4265211 | F | Antidiabetic activity in Sprague-Dawley rat assessed as reduction in blood glucose AUC (0 to 60 mins) at 10 to 20 mg/kg, po administered 60 mins prior to glucose challenge by OGTT | Rattus norvegicus | 3 | ALA4261634 | organism-based format | Scientific Literature | |
| 5. | ALA4265213 | F | Antidiabetic activity in Sprague-Dawley rat assessed as reduction in blood glucose AUC (0 to 120 mins) at 10 to 20 mg/kg, po administered 60 mins prior to glucose challenge by OGTT | Rattus norvegicus | 3 | ALA4261634 | organism-based format | Scientific Literature | |
| 6. | ALA4265214 | A | Cmax in Sprague-Dawley rat at 3 mg/kg, po by LC-ESI-MS analysis | Rattus norvegicus | 1 | ALA4261634 | organism-based format | Scientific Literature | |
| 7. | ALA4265215 | A | AUC (0 to t) in Sprague-Dawley rat at 3 mg/kg, po by LC-ESI-MS analysis | Rattus norvegicus | 1 | ALA4261634 | organism-based format | Scientific Literature | |
| 8. | ALA4265216 | A | Tmax in Sprague-Dawley rat at 3 mg/kg, po by LC-ESI-MS analysis | Rattus norvegicus | 1 | ALA4261634 | organism-based format | Scientific Literature | |
| 9. | ALA4265217 | A | Elimination half life in Sprague-Dawley rat at 3 mg/kg, po by LC-ESI-MS analysis | Rattus norvegicus | 1 | ALA4261634 | organism-based format | Scientific Literature | |
| 10. | ALA4265218 | A | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg by LC-ESI-MS analysis | Rattus norvegicus | 1 | ALA4261634 | organism-based format | Scientific Literature | |
| 11. | ALA4265219 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po by LC-ESI-MS analysis | Rattus norvegicus | 4 | ALA4261634 | organism-based format | Scientific Literature | |
| 12. | ALA4265220 | A | AUC (0 to t) in Sprague-Dawley rat at 10 mg/kg, po by LC-ESI-MS analysis | Rattus norvegicus | 4 | ALA4261634 | organism-based format | Scientific Literature | |
| 13. | ALA4265221 | A | Tmax in Sprague-Dawley rat at 10 mg/kg, po by LC-ESI-MS analysis | Rattus norvegicus | 4 | ALA4261634 | organism-based format | Scientific Literature | |
| 14. | ALA4265222 | A | Elimination half life in Sprague-Dawley rat at 10 mg/kg, po by LC-ESI-MS analysis | Rattus norvegicus | 4 | ALA4261634 | organism-based format | Scientific Literature | |
| 15. | ALA4265223 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-ESI-MS analysis | Rattus norvegicus | 1 | ALA4261634 | organism-based format | Scientific Literature | |
| 16. | ALA4265224 | A | AUC (0 to t) in Sprague-Dawley rat at 1 mg/kg, iv by LC-ESI-MS analysis | Rattus norvegicus | 1 | ALA4261634 | organism-based format | Scientific Literature | |
| 17. | ALA4265225 | A | MRT in Sprague-Dawley rat at 1 mg/kg, iv by LC-ESI-MS analysis | Rattus norvegicus | 1 | ALA4261634 | organism-based format | Scientific Literature | |
| 18. | ALA4265226 | A | Elimination half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-ESI-MS analysis | Rattus norvegicus | 1 | ALA4261634 | organism-based format | Scientific Literature | |
| 19. | ALA4265227 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv by LC-ESI-MS analysis | Rattus norvegicus | 1 | ALA4261634 | organism-based format | Scientific Literature | |
| 20. | ALA4265228 | T | Toxicity in sandwich-cultured Sprague-Dawley rat hepatocytes assessed as inhibition of hepatobiliary transport by measuring biliary excretion index at 5 to 40 uM after 15 mins in presence of d8-TCA by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4261634 | cell-based format | Scientific Literature |
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