| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5254664 | B | Inhibition of DYRK1A (unknown origin) | Homo sapiens | 25 | single protein format | Scientific Literature | ||
| 2. | ALA4266662 | B | Inhibition of DYRK1A Y319E mutant (unknown origin) expressed in HEK293 cells assessed as decrease in tau phosphorylation at Ser97 after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4629321 | B | Inhibition of MELK (unknown origin) | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 4. | ALA5132795 | B | Inhibition of FLAG-tagged full-length human recombinant DYRK1A (127 to 485 residues) expressed in Escherichia coli assessed as reduction in autophosphorylation at Ser97 residue by Western blot analysis | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 5. | ALA5132796 | B | Inhibition of FLAG-tagged full-length human recombinant DYRK1A (127 to 485 residues) expressed in Escherichia coli assessed as reduction in phosphorylated tyrosine level by Western blot analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 6. | ALA5132797 | B | Inhibition of FLAG-tagged full-length human recombinant DYRK1A (127 to 485 residues) expressed in Escherichia coli assessed as reduction in substrate peptide phosphorylation at 32 uM using DYRKtide peptide as substrate incubated for 45 mins in presence of ATP by Kinase-Glo Luminescent kinase assay | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 7. | ALA5132799 | T | Cytotoxicity against HEK293 cells up to 8 uM | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA5132801 | B | Induction of degradation of endogenous FLAG-tagged full-length human recombinant DYRK1A (127 to 485 residues) expressed in Escherichia coli in HEK293 cells assessed as decrease in protein level up to 8 uM measured after 4 days by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5132804 | B | Inhibition of recombinant PKD1 in HEK293 cells at 32 uM using DYRKtide peptide as substrate incubated for 45 mins in presence of ATP by Kinase-Glo Luminescent kinase assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA5132805 | B | Inhibition of recombinant ROCK1 in HEK293 cells at 32 uM using DYRKtide peptide as substrate incubated for 45 mins in presence of ATP by Kinase-Glo Luminescent kinase assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA5132806 | B | Inhibition of HSP90 in HEK293 cells up to 8 uM measured after 4 days by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA5132807 | B | Inhibition of CDC37 in HEK293 cells up to 8 uM measured after 4 days by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA5132808 | B | Inhibition of FYN in HEK293 cells up to 8 uM measured after 4 days by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA5132809 | B | Inhibition of MSK1 in HEK293 cells up to 8 uM measured after 4 days by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA5251363 | B | Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
| 16. | ALA5251364 | B | Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
| 17. | ALA5251365 | B | Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
| 18. | ALA5251366 | B | Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
| 19. | ALA5251367 | B | Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
| 20. | ALA5251368 | B | Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature |
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