# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4257176 | B | Inhibition of recombinant CYP17 (unknown origin) expressed in human AD293 cells using 21[3H]-17alpha-hydroxyl-pregnenolone as substrate pretreated for 60 mins followed by substrate addition and measured after 4 hrs by Topcount method | Homo sapiens | 64 | cell-based format | Patent Bioactivity Data | ||
2. | ALA4257177 | B | Inhibition of recombinant CYP11B1 (unknown origin) expressed in human AD293 cells using 11-deoxycortisol as substrate pretreated for 60 mins followed by substrate addition and measured after 12 hrs by LC/MS analysis | Homo sapiens | 60 | cell-based format | Patent Bioactivity Data | ||
3. | ALA4257178 | B | Inhibition of recombinant CYP21 (unknown origin) expressed in human AD293 cells using 17alpha-hydroxyprogesterone as substrate pretreated for 60 mins followed by substrate addition and measured after 45 mins by LC/MS analysis | Homo sapiens | 62 | cell-based format | Patent Bioactivity Data | ||
4. | ALA4257179 | B | Inhibition of CYP19 (unknown origin) | Homo sapiens | 6 | single protein format | Patent Bioactivity Data | ||
5. | ALA4257180 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 6 | single protein format | Patent Bioactivity Data | ||
6. | ALA4257181 | B | Inhibition of CYP7A (unknown origin) assessed as reduction in bile acid secretion | Homo sapiens | 6 | single protein format | Patent Bioactivity Data | ||
7. | ALA4257182 | A | Cmax in guinea pig at 10 mg/kg, po | Cavia porcellus | 5 | organism-based format | Patent Bioactivity Data | ||
8. | ALA4257183 | A | Tmax in guinea pig at 10 mg/kg, po | Cavia porcellus | 5 | organism-based format | Patent Bioactivity Data | ||
9. | ALA4257184 | A | Half life in guinea pig at 10 mg/kg, po | Cavia porcellus | 4 | organism-based format | Patent Bioactivity Data | ||
10. | ALA4257185 | A | AUC (0 to last) in guinea pig at 10 mg/kg, po | Cavia porcellus | 5 | organism-based format | Patent Bioactivity Data | ||
11. | ALA4257186 | A | AUC (0 to infinity) in guinea pig at 10 mg/kg, po | Cavia porcellus | 4 | organism-based format | Patent Bioactivity Data | ||
12. | ALA4257187 | A | Extrapolated AUC in guinea pig at 10 mg/kg, po | Cavia porcellus | 4 | organism-based format | Patent Bioactivity Data | ||
13. | ALA4257188 | A | Mean residence time (0 to last) in guinea pig at 10 mg/kg, po | Cavia porcellus | 5 | organism-based format | Patent Bioactivity Data | ||
14. | ALA4257189 | A | Oral bioavailability in guinea pig at 10 mg/kg | Cavia porcellus | 5 | organism-based format | Patent Bioactivity Data |