# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4256755 | B | Inhibition of AIM2 in mouse J774A.1 cells assessed as reduction in LPS-stimulated IL-1beta levels at 10 uM incubated for 1 hr with LPS followed by flagellin stimulation for 6 hrs by ELISA | Mus musculus | 4 | cell-based format | Scientific Literature | ||
2. | ALA4256756 | B | Inhibition of NLRC4 in mouse J774A.1 cells assessed as reduction in LPS-stimulated IL-1beta levels at 10 uM incubated for 1 hr with LPS followed by (poly(dA:dT)) stimulation for 8 hrs by ELISA | Mus musculus | 4 | cell-based format | Scientific Literature | ||
3. | ALA4256757 | F | In-vivo inhibition of NLRP3 inflammasome in C57BL/6 mouse assessed as reduction in LPS-induced IL-1beta levels at 0.5 mg/kg, ip pre-treated for 1 hr followed by LPS stimulation for 2.5 hrs by ELISA | Mus musculus | 3 | organism-based format | Scientific Literature | ||
4. | ALA5140066 | B | Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by ATP addition and measured after 30 mins by ELISA | Mus musculus | 29 | cell-based format | Scientific Literature | ||
5. | ALA5140067 | T | Cytotoxicity against mouse J774.A1 cells assessed as cell viability at 10 uM incubated for 4 hrs by MTT assay relative to control | Mus musculus | 29 | cell-based format | Scientific Literature | ||
6. | ALA5140068 | T | Cytotoxicity against HEK293 cells assessed as cell viability at 10 uM incubated for 4 hrs by MTT assay relative to control | Homo sapiens | 29 | cell-based format | Scientific Literature |