| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4270311 | B | Displacement of [3-125I-Tyr11]-SRIF-14 or [3-125I-Tyr11]-SRIF-28 from human SSR5 expressed in CHOK1 cell membranes at 10 uM relative to control | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 2. | ALA4270312 | B | Displacement of [3-125I-Tyr11]-SRIF-14 or [3-125I-Tyr11]-SRIF-28 from human SSR5 expressed in CHOK1 cell membranes | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 3. | ALA4270313 | A | Metabolic stability in human liver microsomes at 1 uM after 30 mins | Homo sapiens | 29 | microsome format | Scientific Literature | ||
| 4. | ALA4270316 | A | Metabolic stability in rhesus monkey liver microsomes at 1 uM after 30 mins | Macaca mulatta | 29 | microsome format | Scientific Literature | ||
| 5. | ALA4270322 | F | Antagonist activity at human SSR5 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 15 mins followed by forskolin addition measured after 1 hr by LANCE assay | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 6. | ALA4270323 | F | Antagonist activity at human SSR5 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation at 8.3 mM preincubated for 15 mins followed by forskolin addition measured after 1 hr by LANCE assay relative to control | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 7. | ALA4270324 | F | Antagonist activity at mouse SSR5 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 15 mins followed by forskolin addition measured after 1 hr by LANCE assay | Mus musculus | 29 | cell-based format | Scientific Literature | ||
| 8. | ALA4270325 | F | Antagonist activity at mouse SSR5 expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation at 8.3 mM preincubated for 15 mins followed by forskolin addition measured after 1 hr by LANCE assay relative to control | Mus musculus | 28 | cell-based format | Scientific Literature | ||
| 9. | ALA4270326 | B | Inhibition of human ERG | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 10. | ALA4270327 | A | Inhibition of Cav1.2 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 11. | ALA4270328 | A | Inhibition of Nav1.5 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 12. | ALA4270329 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 13. | ALA4270330 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 14. | ALA4270331 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 15. | ALA4270332 | A | Activation of PXR (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 16. | ALA4270333 | A | Clearance in Sprague-Dawley rat at 2 mg/kg, po or 1 mg/kg, iv | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 17. | ALA4270334 | A | AUC in Sprague-Dawley rat at 2 mg/kg, po or 1 mg/kg, iv | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 18. | ALA4270335 | A | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 19. | ALA4270336 | A | Half life in Sprague-Dawley rat at 2 mg/kg, po or 1 mg/kg, iv | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 20. | ALA4270337 | F | Antidiabetic activity in high fat diet fed C57BL/6N mouse assessed as reduction in blood glucose AUC (0 to 120 mins) at 10 mg/kg, po pretreated for 60 mins followed by dextrose challenge by OGTT relative to control | Mus musculus | 4 | organism-based format | Scientific Literature |
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