| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4254542 | B | Inhibition of [3H]serotonin reuptake in rat brain synaptosomes SERT at 10 uM after 15 mins by TopCount scintillation counting method relative to control | Rattus norvegicus | 21 | subcellular format | Scientific Literature | ||
| 2. | ALA4254543 | B | Inhibition of [3H]serotonin reuptake in rat brain synaptosomes SERT after 15 mins by TopCount scintillation counting method | Rattus norvegicus | 17 | subcellular format | Scientific Literature | ||
| 3. | ALA4254544 | B | Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes at 10 uM after 60 mins by TopCount scintillation counting method relative to control | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 4. | ALA4254545 | B | Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes after 60 mins by TopCount scintillation counting method | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA4254546 | B | Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes at 10 uM after 120 mins by TopCount scintillation counting method relative to control | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 6. | ALA4254547 | B | Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 7. | ALA4254548 | A | Half life in rat liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 11 | microsome format | Scientific Literature | ||
| 8. | ALA4254549 | A | Clearance in rat liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 11 | microsome format | Scientific Literature | ||
| 9. | ALA4254550 | F | Antidepressant-like activity in mouse assessed as reduction in immobility time at 40 mg/kg/day, po once daily for 7 days measured for last 4 mins of 6 mins test at 1 hr post last dose by forced swim test relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA4254551 | F | Antidepressant-like activity in mouse assessed as reduction in immobility time at 20 mg/kg/day, po once daily for 7 days measured for last 4 mins of 6 mins test at 1 hr post last dose by forced swim test relative to control | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA4254552 | F | Antidepressant-like activity in mouse assessed as reduction in immobility time at 10 mg/kg/day, po once daily for 7 days measured for last 4 mins of 6 mins test at 1 hr post last dose by forced swim test relative to control | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA4254553 | F | Antidepressant-like activity in po dosed mouse assessed as reduction in immobility time administered once daily for 7 days measured for last 4 mins of 6 mins test at 1 hr post last dose by forced swim test | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA4254554 | B | Inhibition of human ERG expressed in CHO-K1 cells assessed as reduction in tail current amplitude at -80 mV holding potential after 2 mins by path clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4254555 | F | Antidepressant-like activity in po dosed mouse assessed as reduction in immobility time administered once daily for 7 days measured for 5 mins at 1 hr post last dose by tail suspension test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4254556 | F | Antidepressant-like activity in mouse assessed as reduction in immobility time at 40 mg/kg/day, po administered once daily for 7 days measured for 5 mins at 1 hr post last dose by tail suspension test relative to control | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA4254557 | F | Antidepressant-like activity in mouse assessed as reduction in immobility time at 20 mg/kg/day, po administered once daily for 7 days measured for 5 mins at 1 hr post last dose by tail suspension test relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4254558 | F | Antidepressant-like activity in mouse assessed as reduction in immobility time at 10 mg/kg/day, po administered once daily for 7 days measured for 5 mins at 1 hr post last dose by tail suspension test relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4254559 | B | Displacement of [3H]prazosin from alpha1-adrenoceptor (unknown origin) in cerebral cortex membranes after 60 mins by TopCount scintillation counting method | Homo sapiens | 2 | cell membrane format | Scientific Literature | ||
| 19. | ALA4254560 | B | Selectivity ratio of Ki for alpha1-adrenoceptor (unknown origin) in cerebral cortex membranes to Ki for recombinant human 5-HT1A receptor expressed in HEK293 cell membranes | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4254561 | A | AUC (0 to t) in Sprague-Dawley rat at 2 mg/kg, po administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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