# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4264789 | Binding | Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assay | Homo sapiens | 26 | ALA4261613 | cell-based format | Scientific Literature | |
2. | ALA4264790 | Binding | Transrepression of recombinant mouse GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assay | Mus musculus | 26 | ALA4261613 | cell-based format | Scientific Literature | |
3. | ALA4264791 | Binding | Displacement of [3H]-Digoxin from recombinant human GST-fused RORgammat LBD after 1 to 4 hrs by scintillation counting method | Homo sapiens | 13 | ALA4261613 | single protein format | Scientific Literature | |
4. | ALA4264792 | Binding | Transrepression of RORgammat in anti-CD3/CD28 stimulated human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by measuring reduction in IL-17A level after 7 days by flow cytometry analysis | Homo sapiens | 9 | ALA4261613 | assay format | Scientific Literature | |
5. | ALA4264793 | Binding | Transrepression of RORgammat in anti-CD3/CD28 stimulated C57BL/6 mouse CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by measuring reduction in IL-17A level after 4 days by ELISA | Mus musculus | 9 | ALA4261613 | assay format | Scientific Literature | |
6. | ALA4264794 | ADME | Stability in human liver microsomes assessed as parent compound remaining after 2 hrs by LC-MS/MS analysis | Homo sapiens | 18 | ALA4261613 | microsome format | Scientific Literature | |
7. | ALA4264795 | ADME | Stability in rat liver microsomes assessed as parent compound remaining after 2 hrs by LC-MS/MS analysis | Rattus norvegicus | 18 | ALA4261613 | microsome format | Scientific Literature | |
8. | ALA4264796 | Physicochemical | Solubility of the compound in NaCl/HCl buffer at pH 1.2 by shake-flask method | 14 | ALA4261613 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4264797 | Physicochemical | Solubility of the compound in KH2PO4/Na2HPO4 buffer at pH 6.8 by shake-flask method | 14 | ALA4261613 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4264798 | Binding | Displacement of [3H]T0901317 from recombinant human GST-fused RORalpha LBD after 1 to 4 hrs by microbeta scintillation counting method | Homo sapiens | 4 | ALA4261613 | single protein format | Scientific Literature | |
11. | ALA4264799 | Binding | Transrepression of recombinant human GAL4-DBD fused RORbeta LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assay | Homo sapiens | 4 | ALA4261613 | cell-based format | Scientific Literature | |
12. | ALA4264800 | Binding | Transrepression of recombinant human GAL4-DBD fused LXRalpha LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assay | Homo sapiens | 4 | ALA4261613 | cell-based format | Scientific Literature | |
13. | ALA4264801 | Binding | Transrepression of recombinant human GAL4-DBD fused LXRbeta LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assay | Homo sapiens | 4 | ALA4261613 | cell-based format | Scientific Literature | |
14. | ALA4264802 | ADME | AUC in rat at 0.5 mg/kg, iv | Rattus norvegicus | 3 | ALA4261613 | organism-based format | Scientific Literature | |
15. | ALA4264803 | ADME | Total clearance in rat at 0.5 mg/kg, iv | Rattus norvegicus | 3 | ALA4261613 | organism-based format | Scientific Literature | |
16. | ALA4264804 | ADME | Half life in rat at 0.5 mg/kg, iv | Rattus norvegicus | 3 | ALA4261613 | organism-based format | Scientific Literature | |
17. | ALA4264805 | ADME | Volume of distribution at steady state in rat at 0.5 mg/kg, iv | Rattus norvegicus | 3 | ALA4261613 | organism-based format | Scientific Literature | |
18. | ALA4264806 | ADME | Cmax in rat at 1 mg/kg, po | Rattus norvegicus | 3 | ALA4261613 | organism-based format | Scientific Literature | |
19. | ALA4264807 | ADME | AUC in rat at 1 mg/kg, po | Rattus norvegicus | 3 | ALA4261613 | organism-based format | Scientific Literature | |
20. | ALA4264808 | ADME | Tmax in rat at 1 mg/kg, po | Rattus norvegicus | 3 | ALA4261613 | organism-based format | Scientific Literature |