# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4275989 | Binding | Inhibition of human IMPDH2 using IMP at 10 uM as substrate in presence of NAD+ after 30 mins relative to control | Homo sapiens | 38 | ALA4270650 | single protein format | Scientific Literature | |
2. | ALA4275990 | Binding | Inhibition of human IMPDH2 using IMP as substrate in presence of NAD+ after 30 mins | Homo sapiens | 38 | ALA4270650 | single protein format | Scientific Literature | |
3. | ALA4423275 | Binding | Inhibition of ABCG2 (unknown origin) expressed in MDCK II BCRP cells assessed as effect on pheophorbide A accumulation after 120 mins by flow cytometric analysis | Homo sapiens | 59 | ALA4422621 | cell-based format | Scientific Literature | |
4. | ALA4423276 | Binding | Inhibition of ABCG2 (unknown origin) expressed in MDCK II BCRP cells assessed as effect on heophorbide A accumulation at 5 to 10 uM after 120 mins by flow cytometric analysis relative to control | Homo sapiens | 59 | ALA4422621 | cell-based format | Scientific Literature | |
5. | ALA4423279 | Binding | Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay | Homo sapiens | 18 | ALA4422621 | cell-based format | Scientific Literature | |
6. | ALA4423280 | Binding | Inhibition of ABCG2 (unknown origin) expressed in MDCK2 cells co-expressing BCRP (unknown origin) assessed as potentiation of SN-38-induced cytotoxicity measured after 72 hrs by MTT assay | Homo sapiens | 13 | ALA4422621 | cell-based format | Scientific Literature | |
7. | ALA4423281 | ADME | Growth inhibition of human A2780 cells after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4422621 | cell-based format | Scientific Literature | |
8. | ALA4423282 | ADME | Growth inhibition of human A2780/ADR cells after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4422621 | cell-based format | Scientific Literature | |
9. | ALA4423283 | ADME | Growth inhibition of MDCK2 cells after 72 hrs by MTT assay | Canis lupus familiaris | 11 | ALA4422621 | cell-based format | Scientific Literature | |
10. | ALA4423284 | ADME | Growth inhibition of MDCK2 cells expressing BCRP (unknown origin) after 72 hrs by MTT assay | Canis lupus familiaris | 11 | ALA4422621 | cell-based format | Scientific Literature | |
11. | ALA4423285 | Toxicity | Therapeutic index, ratio of GI50 for human A2780/ADR cells to EC50 for ABCB1 in human A2780/ADR cells | Homo sapiens | 11 | ALA4422621 | cell-based format | Scientific Literature | |
12. | ALA4423286 | Toxicity | Therapeutic index, ratio of GI50 for MDCK2 cells expressing BCRP (unknown origin) to EC50 for ABCG2 (unknown origin) co-expressed in MDCK2 cells expressing BCRP (unknown origin) | 11 | ALA4422621 | cell-based format | Scientific Literature |