| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4275379 | B | Inhibition of 20S proteasome beta5 subunit in human Jurkat cell lysate using Suc-LLVY-AMC as substrate pretreated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 2. | ALA4275380 | B | Inhibition of yeast 20S proteasome beta1 subunit using fluorescent substrate pretreated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Saccharomyces cerevisiae | 7 | single protein format | Scientific Literature | ||
| 3. | ALA4275381 | B | Inhibition of yeast 20S proteasome beta2 subunit using SUC-RLR-AMC as substrate pretreated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Saccharomyces cerevisiae | 7 | single protein format | Scientific Literature | ||
| 4. | ALA4275382 | B | Inhibition of yeast 20S proteasome beta5 subunit using Suc-LLVY-AMC as substrate pretreated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Saccharomyces cerevisiae | 7 | assay format | Scientific Literature | ||
| 5. | ALA4275383 | F | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 6. | ALA4275384 | F | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 7. | ALA4275385 | F | Cytotoxicity against human RPMI8226 cells after 48 hrs by MTT assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 8. | ALA4275389 | B | Inhibition of 20S proteasome beta5 subunit in human MCF7 cells using Suc-LLVY-AMC as substrate pretreated for 1 hr followed by compound washout and cell lysis prior to substrate addition measured after 1 hr by fluorescence assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 9. | ALA4275390 | B | Inhibition of 20S proteasome beta2 subunit in human Jurkat cell lysate using Suc-RLR-AMC as substrate pretreated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Homo sapiens | 18 | assay format | Scientific Literature | ||
| 10. | ALA4275391 | B | Inhibition of human immunoproteasome beta5 subunit using Suc-RLR-AMC as substrate pretreated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 11. | ALA4275392 | P | n-Octanol/Tris-HCl buffer partition coefficient, log P of the compound at 0.5 mg after 2 mins by RP-HPLC method | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA4275393 | A | Half life in human AB serum by RP-HPLC analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 13. | ALA4275394 | P | Half life in 0.1 M TEAA buffer by RP-HPLC analysis | 1 | small-molecule physicochemical format | Scientific Literature |
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