| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4265762 | B | Inhibition of ACAT in arterial homogenates isolated from 1% cholesterol fed New Zealand White rabbit assessed as reduction in cholesteryl oleate formation incubated for 5 mins in presence of [14C]-oleoyl-CoA and BSA complex by TLC method | Oryctolagus cuniculus | 21 | tissue-based format | Scientific Literature | ||
| 2. | ALA4265763 | B | Inhibition of ACAT in New Zealand White rabbit intestinal microsomes assessed as reduction in cholesteryl oleate formation incubated for 3 mins in presence of [14C]-oleoyl-CoA and BSA complex by TLC method | Oryctolagus cuniculus | 21 | assay format | Scientific Literature | ||
| 3. | ALA4265764 | B | Selectivity ratio of IC50 for ACAT in New Zealand White rabbit intestinal microsomes to IC50 for ACAT in arterial homogenates isolated from 1% cholesterol fed New Zealand White rabbit | Oryctolagus cuniculus | 19 | tissue-based format | Scientific Literature | ||
| 4. | ALA4265765 | B | Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholesterol by cholesterol E-test analysis | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 5. | ALA4265766 | P | Aqueous solubility of the compound at pH 1.2 | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4265767 | A | Tmax in Sprague-Dawley rat at 30 mg/kg, po by LC/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA4265768 | A | Cmax in Sprague-Dawley rat at 30 mg/kg, po by LC/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA4265769 | A | Half life in Sprague-Dawley rat at 30 mg/kg, po by LC/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA4265770 | A | AUC (0 to infinity) in Sprague-Dawley rat at 30 mg/kg, po by LC/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA4265771 | F | Antiatherosclerotic activity in Bio F1B hamster model of diet-induced atherosclerosis assessed as reduction in lipid accumulation areas in aortic arch at 3 mg/kg/day added to chow pellets by oil red O staining based assay relative to control | Cricetinae | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA4265772 | F | Antiatherosclerotic activity in Bio F1B hamster model of diet-induced atherosclerosis assessed as reduction in lipid accumulation areas in aortic arch at 10 mg/kg/day added to chow pellets by oil red O staining based assay relative to control | Cricetinae | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA4265774 | F | Antiatherosclerotic activity in Bio F1B hamster model of diet-induced atherosclerosis assessed as reduction in total plasma cholesterol at 3 mg/kg/day added to chow pellets relative to control | Cricetinae | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA4265775 | F | Antiatherosclerotic activity in Bio F1B hamster model of diet-induced atherosclerosis assessed as reduction in total plasma cholesterol at 10 mg/kg/day added to chow pellets relative to control | Cricetinae | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA4265779 | F | Antiatherosclerotic activity in Bio F1B hamster model of diet-induced atherosclerosis assessed as reduction in CE to FC ratio in lipid accumulation areas at 3 to 30 mg/kg/day added to chow pellets | Cricetinae | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4265780 | T | Toxicity in Bio F1B hamster model of diet-induced atherosclerosis assessed as reduction in CE to FC ratio in adrenal gland at 3 to 30 mg/kg/day added to chow pellets | Cricetinae | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4265783 | T | Genotoxicity in Salmonella typhimurium TA98 by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA4265784 | T | Genotoxicity in Salmonella typhimurium TA100 by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA4265785 | T | Genotoxicity in Salmonella typhimurium TA1537 by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA4265786 | T | Genotoxicity in Salmonella typhimurium TA1535 by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA4265787 | T | Genotoxicity in Escherichia coli WPuvrA by Ames test | Escherichia coli | 3 | organism-based format | Scientific Literature |
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