# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4268683 | B | Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 mins by TR-FRET assay | Homo sapiens | 48 | assay format | Scientific Literature | ||
2. | ALA4268684 | B | Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide substrate addition after 120 mins by fluorescence polarization assay | Homo sapiens | 46 | protein complex format | Scientific Literature | ||
3. | ALA4268685 | B | Inhibition of SYK in human Ramos B cells assessed as reduction in anti-human IgM Fab2 fragment-induced ERK phosphorylation preincubated for 30 mins followed by IgM stimulation for 2 hrs by electro-chemiluminescence assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
4. | ALA4268686 | P | Kinetic solubility in pH 7. PBS buffer after 1 hr by chemi-luminescent nitrogen detection method | 16 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA4268687 | A | Apparent permeability of the compound after 3 hrs by PAMPA | 2 | assay format | Scientific Literature | |||
6. | ALA4268688 | B | Selectivity ratio of IC50 for recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP to IC50 for recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system | Homo sapiens | 3 | assay format | Scientific Literature |