| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4269598 | B | Inhibition of full length His/flag-tagged RIPK2 (unknown origin) expressed in baculovirus expression system using fluorescently labeled substrate incubated for 10 mins followed by substrate addition measured after 10 mins by fluorescence polarization assay | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 2. | ALA4269599 | B | Inhibition of RIPK2 in human whole blood assessed as reduction in MDP-stimulated TNFalpha levels incubated for 30 mins followed by MDP addition measured after 5 hrs | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 3. | ALA4269600 | B | Inhibition of human ERG expressed in CHO cells by Qpatch clamp assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 4. | ALA4269601 | B | Selectivity ratio of IC50 for human ERG to IC50 for RIPK2 in human whole blood | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 5. | ALA4269608 | A | Cmax in Sprague-Dawley rat at 2 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA4269609 | A | AUC in Sprague-Dawley rat at 2 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA4269610 | A | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA4269611 | A | Fraction unbound in Sprague-Dawley rat plasma | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
| 9. | ALA4269612 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as change in QT interval at 0.3 uM by electrophysiology assay | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature | ||
| 10. | ALA4269613 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as change in QT interval at 1 uM by electrophysiology assay | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA4269614 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as change in QT interval at 3 uM by electrophysiology assay | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature | ||
| 12. | ALA4269615 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as change in QT interval at 10 uM by electrophysiology assay | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA4269616 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as prolongation of QT interval by electrophysiology assay | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA4269617 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as Tp-e interval time at 0.3 uM by electrophysiology assay (Rvb = 59.2 +/- 4.8 milliseconds) | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA4269618 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as Tp-e interval time at 1 uM by electrophysiology assay (Rvb = 59.2 +/- 4.8 milliseconds) | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature | ||
| 16. | ALA4269619 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as Tp-e interval time at 3 uM by electrophysiology assay (Rvb = 59.2 +/- 4.8 milliseconds) | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature | ||
| 17. | ALA4269620 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as Tp-e interval time at 10 uM by electrophysiology assay (Rvb = 59.2 +/- 4.8 milliseconds) | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature | ||
| 18. | ALA4269621 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as QRS interval time at 0.3 uM by electrophysiology assay (Rvb = 33.9 +/- 2.7 milliseconds) | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature | ||
| 19. | ALA4269622 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as QRS interval time at 1 uM by electrophysiology assay (Rvb = 33.9 +/- 2.7 milliseconds) | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature | ||
| 20. | ALA4269623 | T | Cardiotoxicity in arterially perfused rabbit cardiac left ventricular wedge assessed as QRS interval time at 3 uM by electrophysiology assay (Rvb = 33.9 +/- 2.7 milliseconds) | Oryctolagus cuniculus | 1 | tissue-based format | Scientific Literature |
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