# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4270091 | Binding | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured MDH refolding after 20 to 40 mins by spectrometric analysis | Escherichia coli | 50 | ALA4266041 | assay format | Scientific Literature | |
2. | ALA4270092 | Binding | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding after 45 mins by spectrometric analysis | Escherichia coli | 50 | ALA4266041 | assay format | Scientific Literature | |
3. | ALA4270093 | Functional | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 6 to 8 hrs by bacterial proliferation assay | Staphylococcus aureus | 50 | ALA4266041 | organism-based format | Scientific Literature | |
4. | ALA4270094 | Binding | Inhibition of refolded rhodanese (unknown origin) preincubated with Escherichia coli GroEL/GroES for 60 mins in absence of compound followed by compound addition by spectrometric analysis | Homo sapiens | 50 | ALA4266041 | single protein format | Scientific Literature | |
5. | ALA4270095 | Binding | Inhibition of refolded MDH (unknown origin) preincubated with Escherichia coli GroEL/GroES for 45 mins in absence of compound followed by compound addition and measured for 20 to 35 mins by spectrometric analysis | Homo sapiens | 50 | ALA4266041 | assay format | Scientific Literature | |
6. | ALA4270096 | Functional | Antibacterial activity against Enterococcus faecium ATCC 19434 after 24 hrs by bacterial proliferation assay | Enterococcus faecium | 50 | ALA4266041 | organism-based format | Scientific Literature | |
7. | ALA4270097 | Functional | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC BAA-44 after 6 to 8 hrs by bacterial proliferation assay | Staphylococcus aureus | 50 | ALA4266041 | organism-based format | Scientific Literature | |
8. | ALA4270098 | Functional | Antibacterial activity against Klebsiella pneumoniae ATCC 13883 after 6 to 8 hrs by bacterial proliferation assay | Klebsiella pneumoniae | 50 | ALA4266041 | organism-based format | Scientific Literature | |
9. | ALA4270099 | Functional | Antibacterial activity against Acinetobacter baumannii ATCC 19606 after 24 hrs by bacterial proliferation assay | Acinetobacter baumannii | 50 | ALA4266041 | organism-based format | Scientific Literature | |
10. | ALA4270100 | Functional | Antibacterial activity against Pseudomonas aeruginosa ATCC 10145 after 24 hrs by bacterial proliferation assay | Pseudomonas aeruginosa | 50 | ALA4266041 | organism-based format | Scientific Literature | |
11. | ALA4270101 | Functional | Antibacterial activity against Enterobacter cloacae subsp. cloacae ATCC 13047 after 24 hrs by bacterial proliferation assay | Enterobacter cloacae | 50 | ALA4266041 | organism-based format | Scientific Literature | |
12. | ALA4270102 | Binding | Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding after 40 to 60 mins by spectrometric analysis | Homo sapiens | 50 | ALA4266041 | assay format | Scientific Literature | |
13. | ALA4270103 | ADME | Cytotoxicity against human THLE3 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay | Homo sapiens | 50 | ALA4266041 | cell-based format | Scientific Literature | |
14. | ALA4270104 | ADME | Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue reporter assay | Homo sapiens | 50 | ALA4266041 | cell-based format | Scientific Literature | |
15. | ALA4270106 | Functional | Ratio of EC50 for bactericidal activity against Staphylococcus aureus Rosenbach ATCC 25923 in biofilms to EC50 for planktonic growth of Staphylococcus aureus Rosenbach ATCC 25923 | Staphylococcus aureus | 5 | ALA4266041 | organism-based format | Scientific Literature | |
16. | ALA4270107 | Functional | Antibiofilm activity against Staphylococcus aureus Rosenbach ATCC 25923 after 24 hrs by crystal-violet based UV-Vis spectroscopy | Staphylococcus aureus | 6 | ALA4266041 | organism-based format | Scientific Literature | |
17. | ALA4270108 | Functional | Bactericidal activity against Staphylococcus aureus Rosenbach ATCC 25923 in biofilms preincubated for 24 hrs followed by compound wash out and measured after 24 hrs | Staphylococcus aureus | 6 | ALA4266041 | organism-based format | Scientific Literature | |
18. | ALA4270109 | Functional | Bactericidal activity against planktonic growth of Staphylococcus aureus Rosenbach ATCC 25923 preincubated for 24 hrs followed by compound wash out and measured after 24 hrs | Staphylococcus aureus | 6 | ALA4266041 | organism-based format | Scientific Literature | |
19. | ALA4822843 | Functional | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by AlamarBlue assay | Homo sapiens | 24 | ALA4819133 | cell-based format | Scientific Literature | |
20. | ALA4822844 | Functional | Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability measured after 48 hrs by AlamarBlue assay | Homo sapiens | 24 | ALA4819133 | cell-based format | Scientific Literature |