| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4276577 | A | Half life in Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4276578 | F | Cognitive enhancing effect in Sprague-Dawley rat assessed as effect on total exploration time for familiar objects in acquisition trial at 0.03 to 0.3 mg/kg, po administered 1 hr measured for 3 mins by novel object recognition test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA4276580 | B | Displacement of [3H]-spiperone from dopamine D2 receptor in rat striatum homogenates after 30 mins by liquid scintillation counting | Rattus norvegicus | 44 | assay format | Scientific Literature | ||
| 4. | ALA4276581 | B | Displacement of [3H]-8-OH-DPAT from serotonin 5-HT1A receptor in rat brain cortex homogenates incubated for 30 mins by liquid scintillation counting | Rattus norvegicus | 44 | assay format | Scientific Literature | ||
| 5. | ALA4276582 | B | Displacement of [3H]-ketanserine from serotonin 5-HT2A receptor in rat brain cortex homogenates incubated for 30 mins by liquid scintillation counting | Rattus norvegicus | 44 | assay format | Scientific Literature | ||
| 6. | ALA4276583 | B | Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting | Cavia porcellus | 6 | assay format | Scientific Literature | ||
| 7. | ALA4276584 | B | Displacement of [3H]-mesulergine from serotonin 5-HT2C receptor in rat brain cerebral cortex homogenates incubated for 15 mins by liquid scintillation counting | Rattus norvegicus | 6 | assay format | Scientific Literature | ||
| 8. | ALA4276585 | A | Displacement of [3H]-prazosin from alpha-1 adrenergic receptor in rat cerebral cortex homogenates incubated for 60 mins by liquid scintillation counting | Rattus norvegicus | 6 | assay format | Scientific Literature | ||
| 9. | ALA4276586 | B | Displacement of [3H]-lysergic acid diethylamide from human serotonin 5-HT6 receptor expressed in CHO cell membranes incubated for 30 mins by liquid scintillation counting | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 10. | ALA4276587 | B | Displacement of [3H] 7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle homogenates after 60 mins by liquid scintillation counting | Rattus norvegicus | 6 | assay format | Scientific Literature | ||
| 11. | ALA4276588 | B | Inhibition of human ERG expressed in HEK293 cells at -50 mV holding potential by patch clamp assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4276589 | T | Acute toxicity in po dosed Kunming mouse assessed as mortality measured after 24 hrs post dose | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4276590 | F | Agonist activity at dopamine D2 receptor long isoform (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux at 10 uM after 60 min by calcium 4-dye based FLIPR assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4276592 | F | Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux at 10 uM after 60 mins by calcium 4-dye based FLIPR assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4276594 | F | Agonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux at 10 uM after 60 mins by calcium 4-dye based FLIPR assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4276596 | F | Agonist activity at serotonin 5-HT2A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux at 10 uM after 60 mins by calcium 4-dye based FLIPR assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4276598 | F | Agonist activity at serotonin 5-HT6 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux at 10 uM after 60 mins by calcium 4-dye based FLIPR assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4276600 | F | Antagonist activity at dopamine D2 receptor long isoform (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux at 10 uM after 15 mins by calcium 4-dye based FLIPR assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4276601 | F | Antagonist activity at dopamine D2 receptor long isoform (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4276602 | F | Antagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux at 10 uM after 15 mins by calcium 4-dye based FLIPR assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!