| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3760529 | F | Agonist activity at recombinant human NMU1 expressed in HEK293 cells assessed as change in intracellular calcium flux by fluorescence assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 2. | ALA3760531 | F | Agonist activity at recombinant human NMU1 expressed in HEK293 cells assessed as change in intracellular calcium flux at 10 uM by fluorescence assay relative to human NmU | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 3. | ALA3760532 | F | Agonist activity at recombinant human NMU2 expressed in HEK293 cells assessed as change in intracellular calcium flux by fluorescence assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 4. | ALA3760534 | F | Agonist activity at recombinant human NMU2 expressed in HEK293 cells assessed as change in intracellular calcium flux at 10 uM by fluorescence assay relative to human NmU | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 5. | ALA3760541 | A | Half life in C57BL/6 mouse at 10 mg/kg by LC/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 6. | ALA3760542 | A | Tmax in C57BL/6 mouse at 10 mg/kg by LC/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 7. | ALA3760545 | A | Metabolic stability in mouse plasma assessed as compound remaining at 25 uM measured at 28 hrs by LC/MS analysis | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 8. | ALA3760546 | A | Metabolic stability in mouse plasma assessed as compound remaining at 25 uM measured after 6 days by LC/MS analysis | Mus musculus | 2 | cell-free format | Scientific Literature | ||
| 9. | ALA3760547 | F | Anorectic activity in DIO C57BL/6 mouse assessed as decrease in body weight at 2.6 mg/kg, sc administered once a week for 21 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA3760548 | T | Toxicity in DIO C57BL/6 mouse assessed as gastric emptying at 2.6 mg/kg, sc administered once a week for 21 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA3760549 | T | Toxicity in DIO C57BL/6 mouse assessed as white blood cells level at 2.6 mg/kg, sc administered once a week for 21 days by hematology analyzer (Rvb = 7.35 +/- 1.21 x 10'6/ml) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA3760550 | T | Toxicity in DIO C57BL/6 mouse assessed as neutrophils level at 2.6 mg/kg, sc administered once a week for 21 days by hematology analyzer (Rvb = 1.3 +/- 0.21 x 10'6/ml) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3760551 | T | Toxicity in DIO C57BL/6 mouse assessed as lymphocytes level at 2.6 mg/kg, sc administered once a week for 21 days by hematology analyzer (Rvb = 4.82 +/- 0.68 x 10'6/ml) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3760746 | T | Toxicity in DIO C57BL/6 mouse assessed as monocytes level at 2.6 mg/kg, sc administered once a week for 21 days by hematology analyzer (Rvb = 1.07 +/- 0.31 x 10'5/ml) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3760747 | T | Toxicity in DIO C57BL/6 mouse assessed as red blood cells level at 2.6 mg/kg, sc administered once a week for 21 days by hematology analyzer (Rvb = 9.17 +/- 0.17 x 10'9/ml) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3760748 | T | Toxicity in DIO C57BL/6 mouse assessed as platelets level at 2.6 mg/kg, sc administered once a week for 21 days by hematology analyzer (Rvb = 5.97 +/- 0.32 x 10'8/ml) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3760752 | F | Antiobesity activity in DIO C57BL/6 mouse assessed as decrease in abdominal fat content at 2.6 mg/kg, sc administered every 2 days for 21 days (Rvb = 8.1 +/- 0.4%) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3760753 | F | Antiobesity activity in DIO C57BL/6 mouse assessed as decrease in abdominal fat content at 2.6 mg/kg, sc administered every 4 days for 21 days (Rvb = 8.1 +/- 0.4%) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3760754 | F | Antiobesity activity in DIO C57BL/6 mouse assessed as decrease in abdominal fat content at 2.6 mg/kg, sc administered every 7 days for 21 days (Rvb = 8.1 +/- 0.4%) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3760763 | A | Drug level in C57BL/6 mouse at 10 mg/kg measured at 12 hrs by LC/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature |
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