# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4149345 | B | Inhibition of Mycobacterium tuberculosis recombinant salicylate ligase MbtA expressed in Escherichia coli using salicylic acid as substrate after 20 mins by [32P]PPi-ATP exchange based scintillation counting analysis | Mycobacterium tuberculosis | 6 | ALA4145560 | assay format | Scientific Literature | |
2. | ALA4149346 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in glycerol alanine salts medium without ferric ammonium citrate at pH 6.6 after 10 to 14 days by broth microdilution method | Mycobacterium tuberculosis | 6 | ALA4145560 | organism-based format | Scientific Literature | |
3. | ALA4149347 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability | Homo sapiens | 6 | ALA4145560 | cell-based format | Scientific Literature | |
4. | ALA4149348 | A | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability | Chlorocebus sabaeus | 6 | ALA4145560 | cell-based format | Scientific Literature | |
5. | ALA4149349 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in glycerol alanine salts medium without ferric ammonium citrate at pH 6.6 after 10 to 14 days in presence of 0.2 to 3.1 uM salicylate by broth microdilution method | Mycobacterium tuberculosis | 4 | ALA4145560 | organism-based format | Scientific Literature | |
6. | ALA4149350 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in glycerol alanine salts medium without ferric ammonium citrate at pH 6.6 after 10 to 14 days in presence of 12.5 uM salicylate by broth microdilution method | Mycobacterium tuberculosis | 5 | ALA4145560 | organism-based format | Scientific Literature | |
7. | ALA4149353 | B | Inhibition of salicylate ligase MbtA in Mycobacterium tuberculosis H37Rv in iron-free GAST medium assessed as reduction in cell-wall associated lipophilic mycobactin-T production at pH 7.4 at 5 times MIC after 27 hrs by LC-MS/MS method relative to control | Mycobacterium tuberculosis H37Rv | 1 | ALA4145560 | single protein format | Scientific Literature | |
8. | ALA4149354 | B | Inhibition of salicylate ligase MbtA in Mycobacterium tuberculosis H37Rv in iron-free GAST medium assessed as reduction in cell-wall associated lipophilic mycobactin-T production at pH 7.4 at 5 times MIC after 70 hrs by LC-MS/MS method relative to control | Mycobacterium tuberculosis H37Rv | 1 | ALA4145560 | single protein format | Scientific Literature | |
9. | ALA4149355 | B | Inhibition of salicylate ligase MbtA in Mycobacterium tuberculosis H37Rv in iron-free GAST medium assessed as reduction in water-soluble carboxymycobactin production at pH 7.4 at 5 times MIC after 27 to 70 hrs by LC-MS/MS method relative to control | Mycobacterium tuberculosis H37Rv | 1 | ALA4145560 | single protein format | Scientific Literature | |
10. | ALA4149356 | A | AUC (0 to 8 hrs) in Sprague-Dawley rat at 25 mg/kg, po administered as single dose via gavage by LC-MS/MS method | Rattus norvegicus | 2 | ALA4145560 | organism-based format | Scientific Literature | |
11. | ALA4149357 | A | AUC (0 to 8 hrs) in Sprague-Dawley rat at 2.5 mg/kg, iv administered as single dose via bolus injection by LC-MS/MS method | Rattus norvegicus | 2 | ALA4145560 | organism-based format | Scientific Literature | |
12. | ALA4149358 | A | Volume of distribution at steady state in Sprague-Dawley rat at 2.5 mg/kg, iv administered as single dose via bolus injection by LC-MS/MS method | Rattus norvegicus | 2 | ALA4145560 | organism-based format | Scientific Literature | |
13. | ALA4149359 | A | Clearance in Sprague-Dawley rat at 2.5 mg/kg, iv administered as single dose via bolus injection by LC-MS/MS method | Rattus norvegicus | 2 | ALA4145560 | organism-based format | Scientific Literature | |
14. | ALA4149360 | A | Elimination half life in Sprague-Dawley rat at 2.5 mg/kg, iv administered as single dose via bolus injection by LC-MS/MS method | Rattus norvegicus | 2 | ALA4145560 | organism-based format | Scientific Literature | |
15. | ALA4149361 | A | Oral bioavailability in Sprague-Dawley rat at 25 mg/kg administered as single dose via gavage by LC-MS/MS method | Rattus norvegicus | 2 | ALA4145560 | organism-based format | Scientific Literature |