# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4689080 | B | Antagonist activity at P2X7R in mouse N2a cells assessed as reduction in ATP-induced calcium influx at 10 uM incubated for 1 hr by Fura-2AM dye based spectrofluorometry relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
2. | ALA4689083 | B | Antagonist activity at P2X7R in mouse N2a cells assessed as reduction in ATP-induced YO-PRO-1 uptake by cells at 10 uM incubated for 1 hr by fluorescence based assay relative to control | Mus musculus | 5 | cell-based format | Scientific Literature | ||
3. | ALA4689087 | B | Antagonist activity at P2X7R in mouse N2a cells assessed as inhibition of ATP-induced ROS production at 10 uM incubated for 1 hr by using H2DCF-DA probe based fluorescence assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
4. | ALA4689088 | B | Antagonist activity at P2X7R in mouse N2a cells assessed as cytoprotective activity against ATP-induced cell death by measuring increase in cell viability at 10 uM incubated for 1 hr followed by ATP addition and measured after 48 hrs by MTT assay relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
5. | ALA4689092 | B | Antagonist activity at P2X7R in mouse N2a cells assessed as inhibition of ATP-induced NO production at 10 uM incubated for 1 hr by using DAF-FM probe based fluorescence assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
6. | ALA5055813 | B | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium-flux measured after 60 mins by FLIPR analysis | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
7. | ALA5055814 | B | Antagonist activity at rat P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium-flux measured after 60 mins by FLIPR analysis | Rattus norvegicus | 14 | cell-based format | Scientific Literature | ||
8. | ALA5055815 | B | Antagonist activity at mouse P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium-flux measured after 60 mins by FLIPR analysis | Mus musculus | 13 | cell-based format | Scientific Literature | ||
9. | ALA5055818 | B | Displacement of [3H]-A-804598 from rat P2X7 receptor expressed in HEK293 cell membrane by in vitro binding assay | Rattus norvegicus | 10 | cell membrane format | Scientific Literature |