| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5128818 | F | Antagonist activity at human alpha2A receptor stably expressed in CHO cells assessed as inhibition of adrenaline-induced response | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 2. | ALA5128819 | F | Antagonist activity at human alpha2C receptor stably expressed in CHO cells assessed as inhibition of adrenaline-induced response | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 3. | ALA5128820 | B | Selectivity ratio of Kb for antagonist activity at human alpha2A receptor stably expressed in CHO cells to Kb for antagonist activity at human alpha2C receptor stably expressed in CHO cells | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 4. | ALA5128821 | A | Clearance in human hepatocytes assessed per million cells at 1 uM | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 5. | ALA5128822 | A | Clearance in rat hepatocytes assessed per million cells at 1 uM | Rattus norvegicus | 21 | cell-based format | Scientific Literature | ||
| 6. | ALA5128823 | P | Lipophilicity, log D of compound at pH 7.4 | 21 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA5128824 | P | Solubility of compound in pH 7.4 buffer at 1 uM | 20 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5128825 | A | Permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 9. | ALA5128826 | A | Permeability across basolateral to apical side in human Caco-2 cells | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 10. | ALA5128827 | A | Efflux ratio of permeability across basolateral to apical side over apical to basolateral side in human Caco-2 cells | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 11. | ALA5237905 | B | Antagonist activity at alpha2a-adrenoceptor (unknown origin) assessed as reduction in adrenaline-induced response by measuring equilibrium binding constant | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 12. | ALA5237906 | B | Antagonist activity at alpha2c-adrenoceptor (unknown origin) assessed as reduction in adrenaline-induced response by measuring equilibrium binding constant | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 13. | ALA5237907 | B | Selectivity index, ratio of Kb for antagonist activity at alpha2a-adrenoceptor (unknown origin) to Kb for antagonist activity at alpha2c-adrenoceptor (unknown origin) | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 14. | ALA5237908 | A | Metabolic stability in human hepatocytes assessed as clearance per 10^6 cells at 1 uM | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 15. | ALA5237909 | A | Metabolic stability in rat hepatocytes assessed as clearance per 10^6 cells at 1 uM | Rattus norvegicus | 12 | cell-based format | Scientific Literature | ||
| 16. | ALA5237910 | P | Lipophilicity, logD of the compound | 12 | small-molecule physicochemical format | Scientific Literature | |||
| 17. | ALA5237911 | P | Solubility of the compound in pH 7.4 buffer | 12 | small-molecule physicochemical format | Scientific Literature | |||
| 18. | ALA5237912 | A | Permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 19. | ALA5237913 | A | Permeability across basolateral to apical side in human Caco-2 cells | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 20. | ALA5237914 | A | Efflux ratio of permeability across basolateral to apical side over apical to basolateral side in human Caco-2 cells | Homo sapiens | 12 | cell-based format | Scientific Literature |
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