# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4426525 | Binding | Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assay | Homo sapiens | 14 | ALA4425124 | cell-based format | Scientific Literature | |
2. | ALA4426526 | Binding | Inhibition of MRP1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport at 10'-4 M after 30 mins by fluorescence assay | Homo sapiens | 14 | ALA4425124 | cell-based format | Scientific Literature | |
3. | ALA4426527 | ADME | Substrate activity at p-gp in human Caco2 cells assessed as ratio of apparent permeability across basolateral to apical over apical to basolateral side at 100 uM after 120 mins by UV-Vis spectroscopy | Homo sapiens | 14 | ALA4425124 | cell-based format | Scientific Literature | |
4. | ALA4426528 | Binding | Activation of MDR1 (unknown origin) ATPase activity expressed in MDCK cells assessed as decrease in ATP level after 2 hrs by ATPlite assay | Homo sapiens | 14 | ALA4425124 | cell-based format | Scientific Literature | |
5. | ALA4426529 | Binding | Inhibition of BCRP (unknown origin) | Homo sapiens | 4 | ALA4425124 | single protein format | Scientific Literature | |
6. | ALA4426530 | ADME | Cytotoxicity against MDCK cells expressing MDR1 assessed as inhibition of cell proliferation at 1 uM after 24 hrs by MTT assay | Canis lupus familiaris | 4 | ALA4425124 | cell-based format | Scientific Literature | |
7. | ALA4426531 | ADME | Cytotoxicity against MDCK cells expressing MDR1 assessed as inhibition of cell proliferation at 0.1 uM after 48 hrs by MTT assay | Canis lupus familiaris | 4 | ALA4425124 | cell-based format | Scientific Literature | |
8. | ALA4426532 | ADME | Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation at 0.1 uM after 24 hrs by MTT assay | Homo sapiens | 4 | ALA4425124 | cell-based format | Scientific Literature |