# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4335435 | A | Growth inhibition of ciprofloxacin-susceptible Escherichia coli DH5[alpha] incubated for 18 hrs by broth microdilution method | Escherichia coli | 22 | ALA4334441 | organism-based format | Scientific Literature | |
2. | ALA4335436 | F | Growth inhibition of Escherichia coli DH5[alpha] expressing ESBL TEM-116 incubated for 18 hrs by broth microdilution method | Escherichia coli | 22 | ALA4334441 | organism-based format | Scientific Literature | |
3. | ALA4335437 | B | Substrate activity at recombinant Escherichia coli full-length N-terminal His-tagged AmpC (20 to 377 residues) expressed in Escherichia coli assessed as Kcat to Km ratio measured every 20 secs for 1 hr by UV absorbance | Escherichia coli | 22 | ALA4334441 | assay format | Scientific Literature | |
4. | ALA4335438 | A | Drug metabolism in TEM-116-deficient Escherichia coli DH5[alpha] assessed as compound hydrolysis at 100 uM incubated for 90 mins by 1H-NMR spectra analysis | Escherichia coli | 2 | ALA4334441 | assay format | Scientific Literature | |
5. | ALA4335440 | A | Prodrug activation in Escherichia coli DH5[alpha] expressing TEM-116 assessed as bacterial TEM-116 mediated compound hydrolysis at 100 uM incubated for 90 mins by 1H-NMR spectra analysis | Bacteria | 2 | ALA4334441 | assay format | Scientific Literature | |
6. | ALA4335441 | A | Prodrug activation in Escherichia coli DH5[alpha] expressing beta-lactamase CTX-M-1 assessed as bacterial CTX-M-1-mediated compound hydrolysis at 100 uM incubated for 60 mins by 1H-NMR spectra analysis | Bacteria | 3 | ALA4334441 | assay format | Scientific Literature | |
7. | ALA4335442 | A | Drug metabolism in CTX-M-1-deficient Escherichia coli DH5[alpha] assessed as compound hydrolysis at 100 uM incubated for 60 mins by 1H-NMR spectra analysis | Escherichia coli | 3 | ALA4334441 | assay format | Scientific Literature | |
8. | ALA4335443 | A | Growth inhibition of ciprofloxacin-susceptible Escherichia coli CFT073 harboring pSU18 incubated for 18 hrs by broth microdilution method | Escherichia coli | 22 | ALA4334441 | organism-based format | Scientific Literature | |
9. | ALA4335444 | F | Growth inhibition of Escherichia coli CFT073 harboring pSU18 and CTX-M-15 incubated for 18 hrs by broth microdilution method | Escherichia coli | 22 | ALA4334441 | organism-based format | Scientific Literature | |
10. | ALA4335445 | A | Prodrug activation in Escherichia coli CFT073 harboring CTX-M-1 assessed as bacterial CTX-M-1-mediated compound hydrolysis incubated for 1 hr by 1H-NMR analysis | Bacteria | 21 | ALA4334441 | assay format | Scientific Literature | |
11. | ALA4335464 | A | Selectivity ratio of MIC for ciprofloxacin-susceptible Escherichia coli CFT073 harboring pSU18 to MIC for ciprofloxacin-susceptible Escherichia coli DH5[alpha] | 21 | ALA4334441 | assay format | Scientific Literature |