| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4424266 | A | Efflux ratio apparent permeability in human Caco2 cells at 10 uM after 2 hrs by UPLC/MS analysis | Homo sapiens | 8 | ALA4422661 | cell-based format | Scientific Literature | |
| 2. | ALA4424267 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM after 2 hrs by UPLC/MS analysis | Homo sapiens | 8 | ALA4422661 | cell-based format | Scientific Literature | |
| 3. | ALA4424268 | B | Antagonist activity at GAL4-VP16-fused KOR (unknown origin) expressed in human U2OS cells co-expressing Tango-OPRK1-BLA assessed as inhibition of U-50488-induced beta-arrestin migration after 4 hrs by FRET assay | Homo sapiens | 26 | ALA4422661 | cell-based format | Scientific Literature | |
| 4. | ALA4424269 | B | Antagonist activity at GAL4-VP16-fused MOR (unknown origin) expressed in human U2OS cells assessed as inhibition of DAMGO-induced beta-arrestin migration preincubated for 30 mins followed by agonist addition and measured after 3 hrs by PathHunter assay | Homo sapiens | 26 | ALA4422661 | cell-based format | Scientific Literature | |
| 5. | ALA4424270 | B | Antagonist activity at GAL4-VP16-fused DOR (unknown origin) expressed in human U2OS cells assessed as inhibition of DAMGO-induced beta-arrestin migration preincubated for 30 mins followed by agonist addition and measured after 3 hrs by PathHunter assay | Homo sapiens | 26 | ALA4422661 | cell-based format | Scientific Literature | |
| 6. | ALA4424271 | B | Selectivity ratio of IC50 for GAL4-VP16-fused MOR (unknown origin) expressed in human U2OS cells to IC50 for GAL4-VP16-fused KOR (unknown origin) expressed in human U2OS cells | Homo sapiens | 26 | ALA4422661 | cell-based format | Scientific Literature | |
| 7. | ALA4424275 | A | Intrinsic clearance in human liver microsomes at 1 uM measured up to 90 mins by LC-MS/MS analysis | Homo sapiens | 12 | ALA4422661 | microsome format | Scientific Literature | |
| 8. | ALA4424276 | A | Intrinsic clearance in rat liver microsomes at 1 uM measured up to 90 mins by LC-MS/MS analysis | Rattus norvegicus | 12 | ALA4422661 | microsome format | Scientific Literature | |
| 9. | ALA4424277 | A | Intrinsic clearance in mouse liver microsomes at 1 uM measured up to 90 mins by LC-MS/MS analysis | Mus musculus | 12 | ALA4422661 | microsome format | Scientific Literature | |
| 10. | ALA4424278 | A | Protein binding in human plasma at 1 uM after 6 hrs by LC-MS/MS analysis | Homo sapiens | 5 | ALA4422661 | cell-free format | Scientific Literature | |
| 11. | ALA4424279 | A | Protein binding in mouse plasma at 1 uM after 6 hrs by LC-MS/MS analysis | Mus musculus | 5 | ALA4422661 | cell-free format | Scientific Literature | |
| 12. | ALA4424280 | A | Protein binding in rat plasma at 1 uM after 6 hrs by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4422661 | cell-free format | Scientific Literature | |
| 13. | ALA4424281 | A | Inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 4 | ALA4422661 | microsome format | Scientific Literature | |
| 14. | ALA4424282 | A | Inhibition of CYP2D6 in human liver microsomes at 10 uM using bufuralol as substrate after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 5 | ALA4422661 | microsome format | Scientific Literature | |
| 15. | ALA4424283 | A | Inhibition of CYP2C9 in human liver microsomes at 10 uM using tolbutamide as substrate after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 4 | ALA4422661 | microsome format | Scientific Literature | |
| 16. | ALA4424284 | A | Inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 4 | ALA4422661 | microsome format | Scientific Literature | |
| 17. | ALA4424285 | B | Inhibition of human ERG expressed in HEK293 cells at 10 uM by Qpatch clamp assay | Homo sapiens | 5 | ALA4422661 | cell-based format | Scientific Literature | |
| 18. | ALA4424287 | B | Inhibition of human Cav1.2 expressed in HEK293 cells at 10 uM by Qpatch clamp assay | Homo sapiens | 4 | ALA4422661 | cell-based format | Scientific Literature | |
| 19. | ALA4424288 | B | Inhibition of human Kir2.1 expressed in HEK293 cells at 10 uM by manual patch clamp assay | Homo sapiens | 4 | ALA4422661 | cell-based format | Scientific Literature | |
| 20. | ALA4424289 | B | Inhibition of human HCN4 expressed in HEK293 cells at 10 uM by manual patch clamp assay | Homo sapiens | 4 | ALA4422661 | cell-based format | Scientific Literature |
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