# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4305223 | B | Inhibition of pig skin LOX using cadaverine hydrochloride as substrate preincubated for 20 mins followed by substrate addition and measured after 45 mins by horseradish peroxidase-coupled amplex red reagent-based fluorescence assay | Sus scrofa | 66 | assay format | Scientific Literature | ||
2. | ALA4305224 | A | Stability in Balb/c mouse liver microsomes assessed as parent compound remaining at 10 uM measured after 30 mins by LC-MS/MS analysis | Mus musculus | 13 | microsome format | Scientific Literature | ||
3. | ALA4305225 | A | Cmax in mouse at 50 mg/kg, po administered via gavage as single dose by MS analysis | Mus musculus | 11 | organism-based format | Scientific Literature | ||
4. | ALA4305226 | A | AUC in mouse at 50 mg/kg, po administered via gavage as single dose by MS analysis | Mus musculus | 11 | organism-based format | Scientific Literature | ||
5. | ALA4305227 | A | Clearance in mouse at 10 mg/kg, iv administered as single dose by MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
6. | ALA4305228 | A | Half life in mouse at 10 mg/kg, iv administered as single dose by MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
7. | ALA4305229 | A | Oral bioavailability in mouse at 50 mg/kg administered via gavage as single dose by MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
8. | ALA4305230 | B | Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate preincubated for 20 mins followed by substrate addition by ROS-Glo assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
9. | ALA4305231 | B | Inhibition of porcine kidney DAO using cadaverine hydrochloride as substrate by ROS-Glo luminescence assay | Sus scrofa | 3 | assay format | Scientific Literature | ||
10. | ALA4305232 | B | Inhibition of recombinant human SSAO expressed in CHO cells by MAO-Glo assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
11. | ALA4305233 | B | Inhibition of MAOA (unknown origin) using MAO substrate measured after 1 hr by luciferin reagent-based MAO-Glo assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
12. | ALA4305234 | B | Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using MAO substrate measured after 1 hr by luciferin reagent-based MAO-Glo assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA4305236 | B | Inhibition of human ERG expressed in CHOK1 cells by Q-patch electrophysiology method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
14. | ALA4305237 | A | Apparent permeability across apical to basal side in human Caco2 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
15. | ALA4305238 | A | Apparent permeability across basal to apical side in human Caco2 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
16. | ALA4421175 | B | Inhibition of horseradish peroxidase incubated for 20 mins with presence of H2O2 by Amplex red dye based method | Armoracia rusticana | 164 | assay format | Patent Bioactivity Data | ||
17. | ALA4421178 | B | Inhibition of pig skin LOX incubated for 45 mins by Amplex red dye based and HRP coupled assay | Sus scrofa | 91 | assay format | Patent Bioactivity Data | ||
18. | ALA4421179 | B | Inhibition of GFP-tagged mouse LOX expressed in in MDCK cysts by confocal imaging analysis | Mus musculus | 4 | cell-based format | Patent Bioactivity Data | ||
19. | ALA4421180 | B | Inhibition of LOXL2 (unknown origin) using H2O2 substrate incubated for 20 mins by luminescence based assay | Homo sapiens | 19 | single protein format | Patent Bioactivity Data | ||
20. | ALA4421182 | B | Inhibition of LOXL2 (unknown origin) using H2O2 substrate incubated for 20 hrs by luminescence based assay | Homo sapiens | 44 | single protein format | Patent Bioactivity Data |