Anti-hypersensitive activity in MCT-induced pulmonary arterial hypertension Sprague-Dawley rat model assessed as mean pulmonary artery pressure at 37.5 mg/kg, po administered daily for 14 days starting from 14 days post-MCT challenge and measured post-last dose by pressure transducer-coupled polygraphy (Rvb = 36 +/- 2.83 mmHg)
Anti-hypersensitive activity in MCT-induced pulmonary arterial hypertension Sprague-Dawley rat model assessed as right ventricular systolic pressure at 37.5 mg/kg, po administered daily for 14 days starting from 14 days post-MCT challenge and measured post-last dose by pressure transducer-coupled polygraphy (Rvb = 59.06 +/- 3.26 mmHg)
Anti-hypersensitive activity in MCT-induced pulmonary arterial hypertension Sprague-Dawley rat model assessed as right ventricular hypertrophy index at 37.5 mg/kg, po administered daily for 14 days starting from 14 days post-MCT challenge and measured post-last dose by pressure transducer-coupled polygraphy (Rvb = 0.69 +/- 0.054 mmHg)
Anti-hypersensitive activity in MCT-induced pulmonary arterial hypertension Sprague-Dawley rat model assessed as mean pulmonary artery pressure at 37.5 mg/kg, po administered daily for 14 days starting from 14 days post-MCT challenge and measured post-last dose in presence of DCA by pressure transducer-coupled polygraphy (Rvb = 36 +/- 2.83 mmHg)
Anti-hypersensitive activity in MCT-induced pulmonary arterial hypertension Sprague-Dawley rat model assessed as right ventricular systolic pressure at 37.5 mg/kg, po administered daily for 14 days starting from 14 days post-MCT challenge and measured post-last dose in presence of DCA by pressure transducer-coupled polygraphy (Rvb = 59.06 +/- 3.26 mmHg)
Anti-hypersensitive activity in MCT-induced pulmonary arterial hypertension Sprague-Dawley rat model assessed as right ventricular hypertrophy index at 37.5 mg/kg, po administered daily for 14 days starting from 14 days post-MCT challenge and measured post-last dose in presence of DCA by pressure transducer-coupled polygraphy (Rvb = 0.69 +/- 0.054 mmHg)
Anti-hypersensitive activity in MCT-induced pulmonary arterial hypertension Sprague-Dawley rat model assessed as pulmonary artery medial thickness at 37.5 mg/kg, po administered daily for 14 days starting from 14 days post-MCT challenge and measured post-last dose by hematoxylin and eosin staining-based microscopic analysis (Rvb = 0.41 +/- 0.051 No_unit)
Anti-hypersensitive activity in MCT-induced pulmonary arterial hypertension Sprague-Dawley rat model assessed as lung fibrosis at 37.5 mg/kg, po administered daily for 14 days starting from 14 days post-MCT challenge and measured post-last dose by Masson's trichrome staining-based microscopic analysis (Rvb = 6.12 +/- 1.66%)