| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4395491 | B | Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 2. | ALA4395492 | B | Inhibition of GCase in human SH-SY5Y cells at 1 nM to 1 mM using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 3. | ALA4395493 | B | Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 4. | ALA4395494 | B | Inhibition of NLGase in human SH-SY5Y cells at 1 nM to 1 mM using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 5. | ALA4395495 | F | Anti-inflammatory activity in human CuFi1 cells assessed as reduction in Pseudomonas aeruginosa PAO1-induced IL-8 mRNA expression level at 0.1 uM pretreated for 1 hr followed by Pseudomonas aeruginosa PAO1 challenge and measured after 4 hrs by RT-PCR analysis relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 6. | ALA4395499 | A | Induction of apoptosis in human CuFi1 cells incubated for 48 hrs by Muse Annexin V based cell counter assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 7. | ALA4395500 | A | Cytotoxicity against human CuFi1 cells assessed as reduction in cell viability incubated for 48 hrs by Muse cell analyser method | Homo sapiens | 9 | cell-based format | Scientific Literature |
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