# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4308175 | B | Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction of Cd2+ influx preincubated for 5 mins followed by CdCl2 addition by calcium-5 fluorescence dye-based FLIPR assay | Homo sapiens | 2 | ALA4304815 | cell-based format | Scientific Literature | |
2. | ALA4388817 | B | Antagonist activity at human TRPV6 expressed in human HEK293 cells assessed as reduction in Ca2+ transport at 2.5 uM incubated for 5 mins by calcium-5 fluorescence dye-based FLIPR assay | Homo sapiens | 1 | ALA4387732 | cell-based format | Scientific Literature | |
3. | ALA4680527 | B | Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assay | Homo sapiens | 16 | ALA4680064 | cell-based format | Scientific Literature | |
4. | ALA4680529 | B | Inhibition of human peYFP-C1 TRPV6 expressed in HEK293 cells assessed as decrease in whole cell calcium current at 0.1 uM at 50 mV holding potential in presence of La3+ by patch clamp assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
5. | ALA4680530 | B | Inhibition of human peYFP-C1 TRPV6 expressed in HEK293 cells assessed as decrease in whole cell calcium current at 10 uM at 50 mV holding potential in presence of La3+ by patch clamp assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
6. | ALA4680535 | A | Inhibition of rat L-type calcium channel (diltiazem site) at 10 uM | Rattus norvegicus | 2 | ALA4680064 | assay format | Scientific Literature | |
7. | ALA4680536 | A | Inhibition of SOCE in human MDA-MB-231 cells at 5 uM pretreated for 20 mins followed by Tg addition for 10 mins followed by CaCl2 addition by FLIPR assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
8. | ALA4680537 | A | Activation of human TRPV1 expressed in HEK293T cells preincubated for 5 mins followed by CaCl2 addition by calcium-5 fluorescence dye based FLIPR assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
9. | ALA4680538 | A | Inhibition of human TRPV1 expressed in HEK293T cells preincubated for 5 mins followed by CaCl2 addition by calcium-5 fluorescence dye based FLIPR assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
10. | ALA4680539 | B | Inhibition of human ERG at 10 uM | Homo sapiens | 2 | ALA4680064 | single protein format | Scientific Literature | |
11. | ALA4680540 | A | Stability in human liver microsomes assessed as half life | Homo sapiens | 2 | ALA4680064 | microsome format | Scientific Literature | |
12. | ALA4680541 | A | Antiproliferative activity against human T47D cells assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
13. | ALA4680542 | A | Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
14. | ALA4680543 | A | Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
15. | ALA4680544 | A | Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
16. | ALA4680545 | A | Antiproliferative activity against wild type human HEK293 cells assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
17. | ALA4680546 | A | Antiproliferative activity human HEK293 cells expressing human TRPV6 assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
18. | ALA4680547 | A | Cytotoxicity against human T47D cells assessed as induction of cell morphological changes at 100 uM by inverted microscopic analysis | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
19. | ALA4680551 | A | Inhibition of human TRPV5 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assay | Homo sapiens | 2 | ALA4680064 | cell-based format | Scientific Literature | |
20. | ALA4680553 | A | Inhibition of rat L-type calcium channel (verapamil site) at 10 uM | Rattus norvegicus | 2 | ALA4680064 | assay format | Scientific Literature |