| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4428988 | B | Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 10 mins followed by protein addition by fluorometric assay | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 2. | ALA4428989 | B | Inhibition of human recombinant AKR1C2 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 10 mins followed by protein addition by fluorometric assay | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 3. | ALA4428990 | B | Selectivity ratio of IC50 for human recombinant AKR1C2 to IC50 for human recombinant AKR1C3 | Homo sapiens | 14 | assay format | Scientific Literature | ||
| 4. | ALA4428991 | B | Inhibition of COX1 in ram seminal vesicles using arachidonic acid as substrate assessed as reduction in PGH2 conversion to PGG2 by measuring TMPD oxidation preincubated for 5 mins followed by substrate/TMPD addition measured for 5 mins by colorimetric assay | Ovis aries | 4 | single protein format | Scientific Literature | ||
| 5. | ALA4428992 | B | Inhibition of COX1 in ram seminal vesicles using arachidonic acid as substrate assessed as reduction in PGH2 conversion to PGG2 by measuring TMPD oxidation at 100 uM preincubated for 5 mins followed by substrate/TMPD addition measured for 5 mins by colorimetric assay | Ovis aries | 2 | single protein format | Scientific Literature | ||
| 6. | ALA4428993 | B | Inhibition of human recombinant AKR1C1 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 10 mins followed by protein addition by fluorometric assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4428994 | B | Selectivity ratio of IC50 for human recombinant AKR1C1 to IC50 for human recombinant AKR1C3 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA4428995 | B | Inhibition of COX2 (unknown origin) using arachidonic acid as substrate assessed as reduction in PGH2 conversion to PGG2 by measuring TMPD oxidation preincubated for 5 mins followed by substrate/TMPD addition measured for 5 mins by colorimetric assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 9. | ALA4428996 | B | Selectivity ratio of IC50 for inhibition of COX1 in ram seminal vesicles to IC50 for human recombinant AKR1C3 | 4 | assay format | Scientific Literature | |||
| 10. | ALA4428998 | B | Effect on 5alpha-DHT-induced activation of AR (unknown origin) expressed in human HeLa13 cells at 10 uM incubated for 20 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4428999 | B | Inhibition of human AKR1C3 expressed in human LNCAP cells assessed as suppression of [3H]delta4-AD-conversion to testosterone at 30 uM incubated for 48 hrs by liquid scintillation counting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4429000 | B | Inhibition of human AKR1C3 expressed in human LNCAP cells assessed as downregulation of delta4-AD-induced PSA expression at 30 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4429003 | B | Inhibition of human recombinant AKR1C2-mediated reduction of [3H]5alpha-DHT at <100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4429005 | B | Competitive inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 10 mins followed by protein addition by fluorometric assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4429006 | B | Competitive inhibition of human recombinant AKR1C3 using assessed as reduction in NADPH-dependent reduction of delat4-androsten-3,17-dione preincubated for 10 mins followed by protein addition by fluorometric assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4429008 | B | Inhibition of human AKR1C3 expressed in human LNCAP cells assessed as downregulation of delta4-AD-induced PSA expression at 30 uM after 24 hrs by densitometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4429009 | B | Ratio of Ki for competitive inhibition of human recombinant AKR1C3 using assessed as reduction in NADPH-dependent reduction of delat4-androsten-3,17-dione to Ki for Competitive inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation | Homo sapiens | 1 | single protein format | Scientific Literature |
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