| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4404573 | F | Antiviral activity against pseudotyped Influenza A virus H5N1 (Goose/Qinghai/59/05) infected in human A549 cells assessed as inhibition of viral replication at 12.5 uM incubated for 48 hrs by luciferase reporter gene assay relative to control | H5N1 subtype | 34 | ALA4402569 | organism-based format | Scientific Literature | |
| 2. | ALA4404574 | F | Antiviral activity against pseudotyped Influenza A virus H5N1 (Goose/Qinghai/59/05) infected in human A549 cells assessed as inhibition of viral replication at incubated for 48 hrs by luciferase reporter gene assay | H5N1 subtype | 14 | ALA4402569 | organism-based format | Scientific Literature | |
| 3. | ALA4404575 | F | Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells incubated for 1 hr and measured after 36 hrs by PR8-PB2 Gaussia luciferase reporter gene assay | Influenza A virus | 15 | ALA4402569 | organism-based format | Scientific Literature | |
| 4. | ALA4404576 | F | Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in human A549 cells assessed as decrease in viral titer at 1 uM by standard plaque assay | Influenza A virus | 5 | ALA4402569 | organism-based format | Scientific Literature | |
| 5. | ALA4404577 | F | Antiviral activity against Influenza A virus (A/Viet Nam/1203/2004(H5N1)) infected in human A549 cells assessed as decrease in viral titer at 1 uM by standard plaque assay | H5N1 subtype | 5 | ALA4402569 | organism-based format | Scientific Literature | |
| 6. | ALA4404578 | F | Antiviral activity against Influenza A virus (A/Viet Nam/1203/2004(H5N1)) infected in human A549 cells assessed as decrease in viral titer at 20 uM by standard plaque assay | H5N1 subtype | 6 | ALA4402569 | organism-based format | Scientific Literature | |
| 7. | ALA4404579 | F | Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells incubated for 1 hr and measured after 36 hrs by PR8-NS1 Gaussia luciferase reporter gene assay | Influenza A virus | 2 | ALA4402569 | organism-based format | Scientific Literature | |
| 8. | ALA4404580 | F | Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells incubated for 1 hr and measured after 36 hrs in presence of 156 nM Oseltamivir carboxylate by PR8-NS1 Gaussia luciferase reporter gene assay | Influenza A virus | 1 | ALA4402569 | organism-based format | Scientific Literature | |
| 9. | ALA4404588 | A | Stability in mouse liver microsomes assessed as compound remaining incubated for 60 mins in presence of NADPH | Mus musculus | 1 | ALA4402569 | microsome format | Scientific Literature | |
| 10. | ALA4404589 | A | Stability in human liver microsomes assessed as compound remaining incubated for 60 mins in presence of NADPH | Homo sapiens | 1 | ALA4402569 | microsome format | Scientific Literature | |
| 11. | ALA4404590 | A | Inhibition of human CYP3A4 | Homo sapiens | 1 | ALA4402569 | single protein format | Scientific Literature | |
| 12. | ALA4404591 | A | Inhibition of human CYP2C9 | Homo sapiens | 1 | ALA4402569 | single protein format | Scientific Literature | |
| 13. | ALA4404592 | T | Selectivity index, ratio of CC50 for MDCK cells to EC50 for antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells by PR8-PB2 Gaussia luciferase reporter gene assay | 1 | ALA4402569 | cell-based format | Scientific Literature | ||
| 14. | ALA4404593 | A | Ratio of Cmax in BALB/c mouse liver at 50 mg/kg, po to EC50 for antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells by PR8-PB2 Gaussia luciferase reporter gene assay | 1 | ALA4402569 | organism-based format | Scientific Literature | ||
| 15. | ALA4404594 | A | Half life in BALB/c mouse plasma at 10 mg/kg, ip | Mus musculus | 1 | ALA4402569 | organism-based format | Scientific Literature | |
| 16. | ALA4404595 | A | Tmax in BALB/c mouse plasma at 10 mg/kg, ip | Mus musculus | 1 | ALA4402569 | organism-based format | Scientific Literature | |
| 17. | ALA4404596 | A | Cmax in BALB/c mouse plasma at 10 mg/kg, ip | Mus musculus | 1 | ALA4402569 | organism-based format | Scientific Literature | |
| 18. | ALA4404597 | A | AUC (0 to 8 hrs) in BALB/c mouse plasma at 10 mg/kg, ip | Mus musculus | 1 | ALA4402569 | organism-based format | Scientific Literature | |
| 19. | ALA4404598 | A | Half life in BALB/c mouse plasma at 5 mg/kg, iv | Mus musculus | 1 | ALA4402569 | organism-based format | Scientific Literature | |
| 20. | ALA4404599 | A | Half life in BALB/c mouse liver at 10 mg/kg, ip | Mus musculus | 1 | ALA4402569 | organism-based format | Scientific Literature |
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