| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4409497 | F | Increase in TNF-alpha production in mouse RAW264.7 cells at 50 uM incubated for 24 hrs by ELISA (Rvb = 1133.56 +/- 46.61 pg/ml) | Mus musculus | 23 | ALA4406860 | cell-based format | Scientific Literature | |
| 2. | ALA4409498 | F | Increase in TNF-alpha production in mouse RAW264.7 cells incubated for 24 hrs by ELISA | Mus musculus | 3 | ALA4406860 | cell-based format | Scientific Literature | |
| 3. | ALA4409499 | F | Increase in TNF-alpha production in mouse BMDM cells incubated for 24 hrs by ELISA | Mus musculus | 3 | ALA4406860 | cell-based format | Scientific Literature | |
| 4. | ALA4409500 | F | Induction of M1-phenotype markers expression in mouse RAW264.7 cells assessed as increase in IL-1beta expression incubated for 1 hr by qRT-PCR | Mus musculus | 1 | ALA4406860 | cell-based format | Scientific Literature | |
| 5. | ALA4409501 | F | Induction of M1-phenotype markers expression in mouse RAW264.7 cells assessed as increase in TNFalpha expression incubated for 1 hr by qRT-PCR | Mus musculus | 1 | ALA4406860 | cell-based format | Scientific Literature | |
| 6. | ALA4409502 | F | Induction of M1-phenotype markers expression in mouse RAW264.7 cells assessed as increase in iNOS expression incubated for 1 hr by qRT-PCR | Mus musculus | 1 | ALA4406860 | cell-based format | Scientific Literature | |
| 7. | ALA4409503 | F | Induction of M1-phenotype markers expression in mouse RAW264.7 cells assessed as increase in IL-12alpha expression incubated for 1 hr by qRT-PCR | Mus musculus | 1 | ALA4406860 | cell-based format | Scientific Literature | |
| 8. | ALA4409504 | F | Inhibition of M2-phenotype markers expression in mouse RAW264.7 cells assessed as decrease in IL-4 -induced CD206 expression incubated for 1 hr by qRT-PCR | Mus musculus | 1 | ALA4406860 | cell-based format | Scientific Literature | |
| 9. | ALA4409505 | F | Inhibition of M2-phenotype markers expression in mouse RAW264.7 cells assessed as decrease in IL-4 -induced in Arg-1 expression incubated for 1 hr by qRT-PCR | Mus musculus | 1 | ALA4406860 | cell-based format | Scientific Literature | |
| 10. | ALA4409506 | F | Inhibition of M2-phenotype markers expression in mouse RAW264.7 cells assessed as decrease in IL-4 -induced in Fizz-1 expression incubated for 1 hr by qRT-PCR | Mus musculus | 1 | ALA4406860 | cell-based format | Scientific Literature | |
| 11. | ALA4409507 | F | Inhibition of M2-phenotype markers expression in mouse RAW264.7 cells assessed as decrease in IL-4 -induced in Ym-1R expression incubated for 1 hr by qRT-PCR | Mus musculus | 1 | ALA4406860 | cell-based format | Scientific Literature | |
| 12. | ALA4409508 | F | Induction of M1-phenotype associated markers in mouse RAW264.7 cells assessed as F4/80-MHC II expression incubated for 24 hrs by flow cytometry (Rvb = 12.1 %) | Mus musculus | 1 | ALA4406860 | cell-based format | Scientific Literature | |
| 13. | ALA4409509 | F | Inhibition of M2-phenotype associated markers in mouse RAW264.7 cells assessed as F4/80-CD206 expression in presence of IL4 incubated for 24 hrs by flow cytometry (Rvb = 7.54 %) | Mus musculus | 1 | ALA4406860 | cell-based format | Scientific Literature | |
| 14. | ALA4409510 | A | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 1000 uM incubated for 24 hrs by CCK-8 assay | Mus musculus | 1 | ALA4406860 | cell-based format | Scientific Literature | |
| 15. | ALA4409511 | F | Antitumor activity against mouse LLC cells xenografted in C57BL/6 mouse assessed as reduction in tumor volume at 5 mg/kg, ip administered every other day for 30 days | Mus musculus | 1 | ALA4406860 | organism-based format | Scientific Literature | |
| 16. | ALA4409512 | F | Antitumor activity against mouse LLC cells xenografted in C57BL/6 mouse assessed as reduction in tumor volume in prescence of anti-PD1 at 5 mg/kg, ip administered every other day for 30 days | Mus musculus | 1 | ALA4406860 | organism-based format | Scientific Literature | |
| 17. | ALA4409513 | F | Antitumor activity against mouse LLC cells xenografted in C57BL/6 mouse assessed as reduction in tumor weight at 5 mg/kg, ip administered every other day for 30 days | Mus musculus | 1 | ALA4406860 | organism-based format | Scientific Literature | |
| 18. | ALA4409514 | F | Antitumor activity against mouse LLC cells xenografted in C57BL/6 mouse assessed as reduction in tumor weight in prescence of anti-PD1 at 5 mg/kg, ip administered every other day for 30 days | Mus musculus | 1 | ALA4406860 | organism-based format | Scientific Literature | |
| 19. | ALA4409515 | T | Toxicity in C57BL/6 mouse xenografted with mouse LLC cells assessed as effect on lungs at 5 mg/kg, ip administered every other day for 30 days by H and E staining based microscopic analysis | Mus musculus | 1 | ALA4406860 | organism-based format | Scientific Literature | |
| 20. | ALA4409516 | T | Toxicity in C57BL/6 mouse xenografted with mouse LLC cells assessed as effect on liver at 5 mg/kg, ip administered every other day for 30 days by H and E staining based microscopic analysis | Mus musculus | 1 | ALA4406860 | organism-based format | Scientific Literature |
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