| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4392025 | F | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 measured after 72 hrs by SYBR Green 1 dye based fluorescence assay | Plasmodium falciparum | 48 | organism-based format | Scientific Literature | ||
| 2. | ALA4392027 | A | Half life in mouse liver microsomes at 1 uM measured after 30 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 11 | microsome format | Scientific Literature | ||
| 3. | ALA4392028 | F | Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR Green 1 dye based fluorescence assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
| 4. | ALA4392029 | F | Potency index, ratio of chloroquine IC50 to test compound IC50 for multidrug-resistant Plasmodium falciparum Dd2 | Plasmodium falciparum | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA4392030 | B | Inhibition of recombinant human C-terminal His10-tagged BACE1 using Mca-SEVNLDAEFRK(Dpn)RR-NH2 as substrate measured after 60 mins by TR-FRET assay | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 6. | ALA4392031 | B | Inhibition of Plasmodium falciparum plasmepsin 2 using EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH as substrate measured after 60 mins by fluorescence assay | Plasmodium falciparum | 10 | single protein format | Scientific Literature | ||
| 7. | ALA4392032 | B | Inhibition of Plasmodium falciparum plasmepsin 4 using EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH as substrate measured after 60 mins by fluorescence assay | Plasmodium falciparum | 10 | single protein format | Scientific Literature | ||
| 8. | ALA4392036 | B | Inhibition of Tracer Red binding to human ERG expressed in membranes by fluorescence polarization assay | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 9. | ALA4392037 | T | Selectivity ratio of IC50 for inhibition of Tracer Red binding to human ERG expressed in membranes to IC50 for chloroquine-sensitive Plasmodium falciparum 3D7 | 10 | assay format | Scientific Literature | |||
| 10. | ALA4392038 | A | Intrinsic clearance in mouse liver microsomes at 1 uM measured after 30 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 10 | microsome format | Scientific Literature | ||
| 11. | ALA4392040 | A | Half life in mouse at 2 mg/kg, iv by LC-MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA4392042 | A | Apparent clearance in mouse at 2 mg/kg, iv by LC-MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA4392044 | A | Apparent volume of distribution in mouse at 2 mg/kg, iv by LC-MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 14. | ALA4392046 | A | Oral bioavailability in mouse at 3 mg/kg by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4392047 | F | Antimalarial activity against chloroquine-resistant Plasmodium chabaudi ASCQ infected in NIH mouse assessed as inhibition of parasitemia at 3 mg/kg, po administered once daily for 4 days starting from 4 hrs post-infection and measured on day 4 by Peter's 4 day test relative to control | Plasmodium chabaudi | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4392048 | F | Antimalarial activity against chloroquine-resistant Plasmodium chabaudi ASCQ infected in NIH mouse assessed as inhibition of parasitemia at 10 mg/kg, po administered once daily for 4 days starting from 4 hrs post-infection and measured on day 4 by Peter's 4 day test relative to control | Plasmodium chabaudi | 2 | organism-based format | Scientific Literature | ||
| 17. | ALA4392049 | F | Antimalarial activity against chloroquine-resistant Plasmodium chabaudi ASCQ infected in NIH mouse assessed as inhibition of parasitemia at 30 mg/kg, po administered once daily for 4 days starting from 4 hrs post-infection and measured on day 4 by Peter's 4 day test relative to control | Plasmodium chabaudi | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4392050 | A | Plasma concentration in NIH mouse infected with chloroquine-resistant Plasmodium chabaudi ASCQ at 3 mg/kg, po administered once daily for 4 days starting from 4 hrs post-infection and measured 1 hr post-last dose by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4392051 | A | Plasma concentration in NIH mouse infected with chloroquine-resistant Plasmodium chabaudi ASCQ at 10 mg/kg, po administered once daily for 4 days starting from 4 hrs post-infection and measured 1 hr post-last dose by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4392052 | A | Plasma concentration in NIH mouse infected with chloroquine-resistant Plasmodium chabaudi ASCQ at 30 mg/kg, po administered once daily for 4 days starting from 4 hrs post-infection and measured 1 hr post-last dose by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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