# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4415677 | ADME | Cytotoxicity against human MRC5 SV2 cells assessed as reduction in cell viability incubated for 3 days by resazurin dye based assay | Homo sapiens | 29 | ALA4414577 | cell-based format | Scientific Literature | |
2. | ALA4415678 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen CL2 amastigotes infected in human MRC5 SV2 cells incubated for 7 days by chlorophenol red beta-D-galactopyranoside substrate based spectrophotometric assay | Trypanosoma cruzi | 29 | ALA4414577 | organism-based format | Scientific Literature | |
3. | ALA4415679 | Toxicity | Selectivity index, ratio for EC50 for human MRC5 SV2 cells to EC50 for Trypanosoma cruzi Tulahuen CL2 amastigotes infected in human MRC5 SV2 cells | 16 | ALA4414577 | cell-based format | Scientific Literature | ||
4. | ALA5135071 | Toxicity | Cytotoxicity against human MRC5 fibroblast cells assessed as reduction in cell viability measured after 3 days by fluorometry | Homo sapiens | 29 | ALA5131491 | cell-based format | Scientific Literature | |
5. | ALA5135073 | Functional | Antitrypanosomal activity against intracellular Trypanosoma cruzi Tulahuen amastigotes expressing CL2 beta-galactosidase in human MRC5 cells assessed as parasite growth inhibition using chlorophenol red beta-D-galactopyranoside as substrate treated for 7 days by spectrophotometry | Trypanosoma cruzi | 30 | ALA5131491 | organism-based format | Scientific Literature | |
6. | ALA5135074 | Toxicity | Selectivity index, ratio of CC50 for human MRC-5 cells to EC50 for antitrypanosomal activity against intracellular Trypanosoma cruzi Tulahuen amastigotes expressing CL2 beta-galactosidase in human MRC5 cells | 21 | ALA5131491 | cell-based format | Scientific Literature | ||
7. | ALA5135075 | Functional | Antileishmanial activity against intracellular Leishmania infantum MHOM/MA(BE)/67 amastigotes infected in Swiss mouse peritoneal macrophages assessed as parasite growth inhibition incubated for 5 days by giemsa staining based microscopic analysis | Leishmania infantum | 30 | ALA5131491 | organism-based format | Scientific Literature | |
8. | ALA5135076 | Toxicity | Cytotoxicity against Swiss mouse peritoneal macrophages assessed as reduction in cell viability measured after 5 days by microscopic analysis | Mus musculus | 29 | ALA5131491 | cell-based format | Scientific Literature | |
9. | ALA5135077 | Toxicity | Selectivity index, ratio of CC50 for Swiss mouse peritoneal macrophages to EC50 for antileishmanial activity against intracellular Leishmania infantum MHOM/MA(BE)/67 amastigotes infected in Swiss mouse peritoneal macrophages | 14 | ALA5131491 | cell-based format | Scientific Literature |