| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4322490 | A | Drug metabolism assessed as recombinant human CYP1A2-mediated 2-[[(R)-3-(2-Amino-pyrimidin-5-yl)-5,6,8a,9-tetrahydro-8H-7-oxa-2,4,4b-triaza-fluoren-1-yl]-(2-hydroxy-ethyl)-amino]-propionaldehyde formation incubated for 60 mins by LC-HRMS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA4322491 | A | Drug metabolism assessed as recombinant human CYP1A1-mediated metabolite formation incubated for 60 mins by LC-HRMS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA4322492 | A | Drug metabolism assessed as recombinant human CYP1A1-mediated 2-[[(R)-3-(2-Amino-pyrimidin-5-yl)-8a,9-dihydro-8H-7-oxa-2,4,4b-triaza-fluoren-1-yl]-(2-hydroxy-ethyl)-amino]-propionaldehyde formation incubated for 60 mins by LC-HRMS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA4322493 | A | Drug metabolism assessed as recombinant human CYP1A1-mediated 2-[[(R)-3-(2-Amino-pyrimidin-5-yl)-5,6,8a,9-tetrahydro-8H-7-oxa-2,4,4b-triaza-fluoren-1-yl]-(2-hydroxy-ethyl)-amino]-propionaldehyde formation incubated for 60 mins by LC-HRMS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA4322494 | B | Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in baculovirus expression system by TR-FRET assay | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 6. | ALA4322495 | B | Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residues incubated for 1 hr by Western blot analysis | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 7. | ALA4322496 | B | Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by Western blot analysis | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 8. | ALA4322497 | B | Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human full-length N-terminal His6-tagged p110alpha/p85alpha expressed in baculovirus expression system by TR-FRET assay | Homo sapiens | 29 | assay format | Scientific Literature | ||
| 9. | ALA4322498 | B | Selectivity ratio of Ki for inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human full-length N-terminal His6-tagged p110alpha/p85alpha expressed in baculovirus expression system to Ki for inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in baculovirus expression system | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 10. | ALA4322499 | A | Substrate activity at recombinant human CYP1A1 expressed in baculovirus infected insect cells assessed as parent compound remaining at 1 uM incubated for 60 mins in presence of NADP+-regenerating system by LC-MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4322500 | A | Substrate activity at recombinant human CYP1A2 expressed in baculovirus infected insect cells assessed as parent compound remaining at 1 uM incubated for 60 mins in presence of NADP+-regenerating system by LC-MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4322501 | A | Substrate activity at recombinant human CYP1A1 expressed in baculovirus infected insect cells assessed as parent compound remaining at 1 uM incubated for 60 mins in absence of NADP+-regenerating system by LC-MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4322502 | A | Substrate activity at recombinant human CYP1A2 expressed in baculovirus infected insect cells assessed as parent compound remaining at 1 uM incubated for 60 mins in absence of NADP+-regenerating system by LC-MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA4322503 | B | Binding affinity to wild-type human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 15. | ALA4322504 | B | Binding affinity to human wild-type partial length PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 16. | ALA4322505 | B | Binding affinity to human wild-type partial length PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 17. | ALA4322506 | B | Binding affinity to human wild-type partial length PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 18. | ALA4322507 | B | Binding affinity to human wild-type partial length PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 19. | ALA4322508 | B | Binding affinity to wild-type human full-length PI4Kbeta (M1 to M828 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 20. | ALA4322509 | B | Binding affinity to human wild-type partial length VPS34 (S282 to H879 residues) expressed in mammalian expression system by kinome scan assay | Homo sapiens | 4 | assay format | Scientific Literature |
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