# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4404535 | F | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation at 10 uM incubated for 7 days by GFP reporter gene assay relative to control | Human adenovirus 5 | 55 | ALA4402567 | organism-based format | Scientific Literature | |
2. | ALA4404536 | F | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation incubated for 7 days by GFP reporter gene assay | Human adenovirus 5 | 55 | ALA4402567 | organism-based format | Scientific Literature | |
3. | ALA4404537 | A | Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay | Homo sapiens | 55 | ALA4402567 | cell-based format | Scientific Literature | |
4. | ALA4404538 | T | Selectivity index, ratio of CC50 for cytotoxicity against human A549 cells to IC50 for antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation after 7 days | 55 | ALA4402567 | cell-based format | Scientific Literature | ||
5. | ALA4404539 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral entry at 50 uM after 48 hrs by GFP reporter gene based assay relative to control | Human adenovirus 5 | 10 | ALA4402567 | organism-based format | Scientific Literature | |
6. | ALA4404540 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral entry after 48 hrs by GFP reporter gene based assay | Human adenovirus 5 | 10 | ALA4402567 | organism-based format | Scientific Literature | |
7. | ALA4404545 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as fold reduction in virus yield at 50 uM after 48 hrs endpoint dilution method relative to control | Human adenovirus 5 | 3 | ALA4402567 | organism-based format | Scientific Literature | |
8. | ALA4404547 | F | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of viral infection at 10 uM preincubated for 60 mins followed by viral infection by GFP reporter gene assay relative to control | Human adenovirus 5 | 1 | ALA4402567 | organism-based format | Scientific Literature | |
9. | ALA4404549 | F | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of viral infection at 10 uM measured after 2 hrs post infection by GFP reporter gene assay relative to control | Human adenovirus 5 | 1 | ALA4402567 | organism-based format | Scientific Literature | |
10. | ALA4404559 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells asssessed as inhibition of viral entry by measuring nuclear-associated viral genome level at 50 uM after 45 mins by RT-PCR analysis (Rvb = 100.24 +/- 2.77%) | Human adenovirus 5 | 3 | ALA4402567 | organism-based format | Scientific Literature | |
11. | ALA4404564 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral DNA replication by measuring number of viral DNA copies at 50 uM after 24 hrs by RT-qPCR analysis (Rvb = 100 +/- 1.55%) | Human adenovirus 5 | 3 | ALA4402567 | organism-based format | Scientific Literature | |
12. | ALA4404566 | F | Antiviral activity against Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral DNA replication at 70 uM after 24 hrs by RT-qPCR analysis relative to control | Human adenovirus 5 | 1 | ALA4402567 | organism-based format | Scientific Literature |