# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4407229 | B | Inhibition of 17beta-HSD3 (unknown origin) expressed in human LNCAP cells assessed as reduction in [14C]-testosterone formation from [14C]-4-androstene-3,17-dione at 0.1 uM measured after 1 hr relative to control | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
2. | ALA4407230 | B | Inhibition of 17beta-HSD3 (unknown origin) expressed in human LNCAP cells assessed as reduction in [14C]-testosterone formation from [14C]-4-androstene-3,17-dione at 0.5 uM measured after 1 hr relative to control | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
3. | ALA4407231 | B | Inhibition of 17beta-HSD3 (unknown origin) expressed in human LNCAP cells assessed as reduction in [14C]-testosterone formation from [14C]-4-androstene-3,17-dione at 1 uM measured after 1 hr relative to control | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
4. | ALA4407232 | B | Inhibition of 17beta-HSD3 (unknown origin) expressed in human LNCAP cells assessed as reduction in [14C]-testosterone formation from [14C]-4-androstene-3,17-dione measured after 1 hr | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
5. | ALA4407237 | A | Stability of the compound in human liver S9 fraction at 10 uM measured after 1 hr by NADPH by HPLC-MS analysis | Homo sapiens | 6 | subcellular format | Scientific Literature | ||
6. | ALA4407238 | A | Plasma concentration in mouse at 25 mg/kg, sc administered as single dose measured after 3 hrs by LC-MS/MS analysis | Mus musculus | 6 | organism-based format | Scientific Literature | ||
7. | ALA4407239 | F | Antiproliferative activity against human LAPC4 cells expressing androgen receptor assessed as inhibition of cell proliferation at 0.1 uM supplemented with fresh medium containing compounds every 3 days for 7 days by MTS assay relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
8. | ALA4407240 | F | Antiproliferative activity against human LAPC4 cells expressing androgen receptor assessed as inhibition of cell proliferation at 0.5 uM supplemented with fresh medium containing compounds every 3 days for 7 days by MTS assay relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
9. | ALA4407241 | F | Antiproliferative activity against human LAPC4 cells expressing androgen receptor assessed as inhibition of cell proliferation at 1 uM supplemented with fresh medium containing compounds every 3 days for 7 days by MTS assay relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
10. | ALA4407243 | F | Antiproliferative activity against AR-deficient human PC3 cells assessed as reduction in cell proliferation at 0.1 uM measured after 3 days by MTS assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
11. | ALA4407244 | F | Antiproliferative activity against AR-deficient human PC3 cells assessed as reduction in cell proliferation at 0.5 uM measured after 3 days by MTS assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
12. | ALA4407245 | F | Antiproliferative activity against AR-deficient human PC3 cells assessed as reduction in cell proliferation at 1 uM measured after 3 days by MTS assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
13. | ALA4407251 | F | Antiproliferative activity against human LAPC4 cells expressing androgen receptor assessed as inhibition of cell proliferation supplemented with fresh medium containing compounds every 3 days for 7 days by MTS assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
14. | ALA4407252 | B | Potency index, ratio of RM-532-105 IC50 to test compound IC50 for 17beta-HSD3 (unknown origin) expressed in human LNCAP cells | Homo sapiens | 5 | cell-based format | Scientific Literature |