| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4361557 | F | Antiarthritic activity in Lewis rat model of complete Freund's adjuvant-induced arthritis assessed as reduction in mean articular index score at 1 nmol/g administered intra-articularly into knee joint for 6 weeks and measured every week during compound dosing | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4361558 | B | Binding affinity to recombinant human TLR4 using phage displayed compound by Phage-ELISA | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 3. | ALA4361561 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced TNFalpha secretion after 24 hrs by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4361572 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced IL-6 secretion after 24 hrs by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4361600 | B | Antagonist activity at TLR7/8 in human THP1 cells assessed as reduction in R848-induced IL6 secretion at 50 uM after 24 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4361602 | B | Antagonist activity at TLR9 in human THP1 cells assessed as reduction in CpG ODN-induced IL6 secretion at 50 uM after 24 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4361603 | B | Binding affinity to recombinant human TLR4 by surface plasmon resonance analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 8. | ALA4361604 | B | Binding affinity to recombinant human MD2 by surface plasmon resonance analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 9. | ALA4361605 | B | Binding affinity to recombinant human TLR4 assessed as association constant up to 200 uM by surface plasmon resonance analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 10. | ALA4361606 | B | Binding affinity to recombinant human TLR4 assessed as dissociation constant up to 200 uM by surface plasmon resonance analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 11. | ALA4361607 | B | Binding affinity to recombinant human MD2 assessed as association constant up to 200 uM by surface plasmon resonance analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA4361608 | B | Binding affinity to recombinant human MD2 assessed as dissociation constant up to 200 uM by surface plasmon resonance analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA4361610 | A | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 5 to 50 uM after 24 hrs by MTT assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4361611 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced IFNalpha secretion at 5 to 50 uM after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4361612 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced IFNbeta secretion at 5 to 50 uM after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4361613 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced extracellular NO secretion at 5 to 50 uM by spectrophotometric method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4361614 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced cytosolic NO level at 50 uM by DAF-FM staining based FACS analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4361615 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced cytosolic ROS level at 50 uM by DCF-DA staining based FACS analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4361616 | B | Antagonist activity at TLR4 in human THP1 cells assessed as reduction in LPS-induced IL6 secretion at 50 uM after 24 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4361617 | B | Antagonist activity at TLR2/1 in human THP1 cells assessed as reduction in PAM3CSK4-induced IL6 secretion at 50 uM after 24 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature |
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