| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4433517 | A | Growth inhibition of human CCD-841-CoN cells after 72 hrs by CellTiter-Blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4433518 | F | Growth inhibition of human SW948 cells after 72 hrs by CellTiter-Blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA4433519 | F | Growth inhibition of human HCT116 cells after 72 hrs by CellTiter-Blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4433520 | B | Inhibition of recombinant human N-terminal His6-tagged/SUMO-fused SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 assessed as reduction in deacetylase activity using acetylated H3K9 as substrate preincubated for 15 mins followed by substrate addition and measured after 6 mins by UV-HPLC analysis | Homo sapiens | 14 | assay format | Scientific Literature | ||
| 5. | ALA4433521 | B | Inhibition of human SIRT1 deacetylase activity using acetylated H3K9 as substrate preincubated for 15 mins followed by substrate addition and measured after 3 mins by UV-HPLC analysis | Homo sapiens | 13 | single protein format | Scientific Literature | ||
| 6. | ALA4433522 | B | Inhibition of human SIRT3 assessed as reduction in deacetylase activity using acetylated H3K9 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins by UV-HPLC analysis | Homo sapiens | 13 | single protein format | Scientific Literature | ||
| 7. | ALA4433523 | B | Selectivity ratio of IC50 for human SIRT1 to IC50 for recombinant human N-terminal His6-tagged/SUMO-fused SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 8. | ALA4433525 | F | Growth inhibition of human MCF7 cells after 72 hrs by CellTiter-Blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4433526 | F | Growth inhibition of human MDA-MB-468 cells after 72 hrs by CellTiter-Blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4433527 | F | Growth inhibition of human MDA-MB-231 cells after 72 hrs by CellTiter-Blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4433528 | F | Growth inhibition of human BxPC3 cells after 72 hrs by CellTiter-Blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4433529 | F | Growth inhibition of human NCI-H23 cells after 72 hrs by CellTiter-Blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4433530 | F | Growth inhibition of human A549 cells after 72 hrs by CellTiter-Blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA4433531 | A | Cytotoxicity against human HME1 cells after 72 hrs by CellTiter-Blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4433532 | F | Potency index, ratio of TM GI50 to compound GI50 for growth inhibition of human MCF7 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4433533 | F | Potency index, ratio of TM GI50 to compound GI50 for growth inhibition of human MDA-MB-231 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4433534 | F | Potency index, ratio of TM GI50 to compound GI50 for growth inhibition of human A549 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4433535 | F | Potency index, ratio of TM GI50 to compound GI50 for growth inhibition of human SW948 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4433536 | F | Potency index, ratio of TM GI50 to compound GI50 for growth inhibition of human HCT116 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4433537 | F | Inhibition of anchorage-independent cell growth in human HCT116 cells assessed as reduction in colony formation incubated for 5 days followed by compound re-addition and measured after 9 to 11 days by nitro blue tetrazolium chloride-based soft agar colony formation assay | Homo sapiens | 3 | cell-based format | Scientific Literature |
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