# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4430040 | B | Inhibition of recombinant PI3Kalpha (unknown origin) using phosphatidyl inositol as substrate after 30 to 60 mins in presence of ATP by Kinase Glo luminescence assay | Homo sapiens | 16 | single protein format | Scientific Literature | ||
2. | ALA4430042 | B | Inhibition of PI3Kgamma (unknown origin) assessed as reduction in ADP formation using phosphatidyl inositol as substrate after 30 to 60 mins by TR-FRET assay | Homo sapiens | 16 | single protein format | Scientific Literature | ||
3. | ALA4430043 | B | Inhibition of human PI3Kalpha expressed in rat-1 fibroblasts assessed as reduction in Akt phosphorylation at Ser 473 after 1 hr by alphascreen assay | Homo sapiens | 12 | assay format | Scientific Literature | ||
4. | ALA4430044 | B | Inhibition of recombinant PI3Kbeta (unknown origin) using phosphatidyl inositol as substrate after 30 to 60 mins in presence of ATP by Kinase Glo luminescence assay | Homo sapiens | 16 | single protein format | Scientific Literature | ||
5. | ALA4430045 | B | Inhibition of PI3Kdelta (unknown origin) assessed as reduction in ADP formation using phosphatidyl inositol as substrate after 30 to 60 mins by TR-FRET assay | Homo sapiens | 16 | single protein format | Scientific Literature | ||
6. | ALA4430046 | B | Inhibition of human mTOR after 60 mins in presence of [gamma-33P]-ATP by microplate scintillation counting | Homo sapiens | 5 | single protein format | Scientific Literature | ||
7. | ALA4430047 | B | Inhibition of human PI3Kbeta expressed in rat-1 fibroblasts assessed as reduction in Akt phosphorylation at Ser 473 after 1 hr by alphascreen assay | Homo sapiens | 12 | assay format | Scientific Literature | ||
8. | ALA4430048 | B | Inhibition of human PI3Kdelta expressed in rat-1 fibroblasts assessed as reduction in Akt phosphorylation at Ser 473 after 1 hr by alphascreen assay | Homo sapiens | 12 | assay format | Scientific Literature | ||
9. | ALA4430049 | B | Inhibition of PI3Kdelta in Balb/c mouse B cells assessed as reduction in anti-IgM induced CD86 expression preincubated for 1 hr followed by anti-IgM stimulation for 24 hrs by flow cytometry | Mus musculus | 12 | cell-based format | Scientific Literature | ||
10. | ALA4430050 | A | Effective permeability of the compound at pH 6.8 by PAMPA | 12 | assay format | Scientific Literature | |||
11. | ALA4430051 | B | Displacement of [3H]dofetilide from recombinant human ERG transfected in HEK293 cell membranes after 60 mins by scintillation counting | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
12. | ALA4430052 | P | Octanol/water partition coefficient, log P of the compound by high-throughput assay | 12 | small-molecule physicochemical format | Scientific Literature | |||
13. | ALA4430053 | A | Intrinsic clearance in rat liver microsomes assessed per mg protein | Rattus norvegicus | 12 | microsome format | Scientific Literature | ||
14. | ALA4430054 | P | Equilibrium solubility of the compound at pH 6.8 by high-throughput assay | 12 | small-molecule physicochemical format | Scientific Literature | |||
15. | ALA4430086 | B | Selectivity ratio of IC50 for PI3Kdelta in Balb/c mouse B cells to IC50 for human PI3Kdelta expressed in rat-1 fibroblasts | 2 | cell-based format | Scientific Literature |